Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.71 |
| ▸ | CTSD | P07339 | 12/20 | 0.62 |
| ▸ | BACE2 | Q9Y5Z0 | 7/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.47 |
| ▸ | REN | P00797 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL2281054 | 0.95 | BACE1 (0.65) | BACE1CTSDBACE2KCNH2REN | |
| SCHEMBL7875661 | 0.94 | BACE1 (0.70) | BACE1CTSDBACE2KCNH2REN | |
| SCHEMBL12376218 | 0.92 | BACE1 (0.71) | BACE1CTSDBACE2KCNH2REN | |
| SCHEMBL7872670 | 0.89 | BACE1 (0.57) | BACE1CTSDBACE2KCNH2REN | |
| SCHEMBL7865201 | 0.89 | BACE1 (0.57) | BACE1CTSDBACE2KCNH2 | |
| SCHEMBL7863696 | 0.89 | BACE1 (0.62) | BACE1CTSDBACE2KCNH2 | |
| SCHEMBL7864937 | 0.88 | BACE1 (0.75) | BACE1CTSDBACE2KCNH2REN | |
| Formic Acid SCHEMBL2284111 | 0.87 | BACE1 (0.64) | BACE1CTSDBACE2KCNH2REN | |
| SCHEMBL7872518 | 0.87 | BACE1 (0.70) | BACE1CTSDBACE2KCNH2 | |
| SCHEMBL7870271 | 0.87 | BACE1 (0.76) | BACE1CTSDBACE2KCNH2REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245019-B1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-11-14 | — | — | EP | disclosed |
| US-7989449-B2 | 4,5-dihydro-oxazol-2-yl amine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-08-02 | — | — | US | disclosed |
| US-7989449-B2 | 4,5-dihydro-oxazol-2-yl amine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-08-02 | — | — | US | disclosed |