Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 5/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | CDK2AP1 | O14519 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1163022 | 0.95 | MAPK1 (0.59) | CHEK1MAPK1OPRK1NPC1RAB9A | |
| SCHEMBL28280152 | 0.95 | MAPK1 (0.59) | CHEK1MAPK1OPRK1NPC1RAB9A | |
| SCHEMBL1163023 | 0.95 | MAPK1 (0.59) | CHEK1MAPK1OPRK1NPC1RAB9A | |
| SCHEMBL1250846 | 0.89 | MEN1 (0.54) | MAPK1OPRK1NPC1RAB9AHDAC4 | |
| SCHEMBL5230051 | 0.89 | MEN1 (0.54) | MAPK1OPRK1NPC1RAB9AHDAC4 | |
| SCHEMBL8491815 | 0.89 | MEN1 (0.54) | MAPK1OPRK1NPC1RAB9AHDAC4 | |
| Hydrochloric Acid SCHEMBL28156652 | 0.88 | MEN1 (0.53) | MAPK1OPRK1NPC1RAB9AHDAC4 | |
| Hydrochloric Acid SCHEMBL994487 | 0.88 | MEN1 (0.53) | MAPK1OPRK1NPC1RAB9AHDAC4 | |
| Hydrochloric Acid SCHEMBL28155972 | 0.88 | MEN1 (0.53) | MAPK1OPRK1NPC1RAB9AHDAC4 | |
| Cadaverine Tartrate SCHEMBL28008723 | 0.88 | MAPK1 (0.52) | CHEK1MAPK1OPRK1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1085888-A1 | MULTIVALENT AGONISTS, PARTIAL AGONISTS, INVERSE AGONISTS AND ANTAGONISTS OF THE 5-HT 3? RECEPTORS | Advanced Medicine, Inc. (US) | 2001-03-28 | — | — | EP | disclosed |
| WO-1999064046-A9 | MULTIVALENT AGONISTS, PARTIAL AGONISTS, INVERSE AGONISTS AND ANTAGONISTS OF THE 5-HT3 RECEPTORS | ADVANCED MEDICINE INC (US) | 2000-04-20 | — | — | WO | disclosed |
| WO-1999064046-A1 | MULTIVALENT AGONISTS, PARTIAL AGONISTS, INVERSE AGONISTS AND ANTAGONISTS OF THE 5-HT3 RECEPTORS | ADVANCED MEDICINE, INC. (US) | 1999-12-16 | — | — | WO | disclosed |