SCHEMBL7865277

SCHEMBL7865277

C=Cc1cccc([Si](C)(C)N[Si](C)(C)c2cccc(C=C)c2)c1

nearest known ligand 0.48

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
ALDH1A1 P00352 2/20 0.38
TSHR P16473 1/20 0.38
HDAC8 Q9BY41 1/20 0.33
PTGS2 P35354 1/20 0.33
TGFBR1 P36897 1/20 0.32
MEN1 O00255 1/20 0.31
POLB P06746 1/20 0.31
KMT2A Q03164 1/20 0.31
TRPA1 O75762 1/20 0.31
FAAH O00519 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3157051 0.82 TP53 (0.54) TP53TDP1ALDH1A1TSHRHDAC8
SCHEMBL29434596 0.78 TP53 (0.50) TP53TDP1ALDH1A1TSHRHDAC8
SCHEMBL7799260 0.78 TP53 (0.50) TP53TDP1ALDH1A1TSHRHDAC8
SCHEMBL10621571 0.78 TP53 (0.50) TP53TDP1ALDH1A1TSHRHDAC8
SCHEMBL15473031 0.78 TP53 (0.50) TP53TDP1ALDH1A1TSHRHDAC8
SCHEMBL23493442 0.78 TP53 (0.50) TP53TDP1ALDH1A1TSHRHDAC8
SCHEMBL29434648 0.78 TP53 (0.50) TP53TDP1ALDH1A1TSHRHDAC8
SCHEMBL9715838 0.78 TP53 (0.50) TP53TDP1ALDH1A1TSHRHDAC8
SCHEMBL16033452 0.76 TP53 (0.47) TP53TDP1ALDH1A1TSHRHDAC8
SCHEMBL23493485 0.76 TP53 (0.47) TP53TDP1ALDH1A1TSHRHDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6307081-B1 MACROMONOMER HAS ONE OR MORE SILICON-BONDED HYDROGEN ATOMS AT ONE MOLECULAR CHAIN TERMINAL, AND ONE OR MORE ALIPHATICALLY UNSATURATED SILICON-BONDED ORGANIC GROUPS AT THE OTHER MOLECULAR CHAIN TERMINAL. DOW CORNING SILICONE COMPANY, LTD. (JP) 2001-10-23 US disclosed