Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Naratriptan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D known ✓ | P28221 | 9/20 | 0.76 |
| ▸ | HTR1B known ✓ | P28222 | 9/20 | 0.76 |
| ▸ | HTR1A | P08908 | 7/20 | 0.76 |
| ▸ | HTR5A | P47898 | 9/20 | 0.66 |
| ▸ | HTR2A | P28223 | 3/20 | 0.66 |
| ▸ | HTR2B | P41595 | 2/20 | 0.66 |
| ▸ | HTR7 | P34969 | 2/20 | 0.66 |
| ▸ | HTR2C | P28335 | 2/20 | 0.66 |
| ▸ | HTR1E | P28566 | 1/20 | 0.66 |
| ▸ | HTR1F | P30939 | 1/20 | 0.66 |
| ▸ | HTR3A | P46098 | 1/20 | 0.66 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Naratriptan SCHEMBL8716118 | 0.88 | HTR1D (0.70) | HTR1DHTR1BHTR1AHTR5AHTR2A | |
| Naratriptan SCHEMBL6235276 | 0.88 | HTR1D (0.64) | HTR1DHTR1BHTR1AHTR5AHTR2A | |
| Naratriptan SCHEMBL29403931 | 0.87 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR1FHTR6 | |
| Naratriptan SCHEMBL68753 | 0.87 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR1FHTR6 | |
| Naratriptan SCHEMBL4946618 | 0.87 | HTR1D (0.65) | HTR1DHTR1BHTR1AHTR5AHTR2A | |
| Naratriptan SCHEMBL12803311 | 0.86 | HTR1D (0.98) | HTR1DHTR1BHTR1AHTR1FHTR6 | |
| Naratriptan SCHEMBL30903899 | 0.86 | HTR1D (0.98) | HTR1DHTR1BHTR1AHTR1FHTR6 | |
| Naratriptan SCHEMBL41527 | 0.86 | HTR1D (0.98) | HTR1DHTR1BHTR1AHTR1FHTR6 | |
| Naratriptan SCHEMBL28587084 | 0.86 | HTR1D (0.98) | HTR1DHTR1BHTR1AHTR1FHTR6 | |
| Naratriptan SCHEMBL8716122 | 0.86 | HTR1D (0.68) | HTR1DHTR1BHTR1AHTR5AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699572-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143143-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | disclosed |
| EP-1083918-A1 | NOVEL THERAPEUTIC AGENTS THAT MODULATE 5-HT RECEPTORS | Advanced Medicine, Inc. (US) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999064044-A1 | NOVEL THERAPEUTIC AGENTS THAT MODULATE 5-HT RECEPTORS | ADVANCED MEDICINE, INC. (US) | 1999-12-16 | — | — | WO | disclosed |