Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Naratriptan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D known ✓ | P28221 | 16/20 | 0.68 |
| ▸ | HTR1B known ✓ | P28222 | 16/20 | 0.68 |
| ▸ | HTR1A | P08908 | 4/20 | 0.68 |
| ▸ | HTR1F | P30939 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR1E | P28566 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | HTR5A | P47898 | 1/20 | 0.47 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Naratriptan SCHEMBL7865288 | 0.86 | HTR1D (0.76) | HTR1DHTR1BHTR1AHTR1FHTR2A | |
| Naratriptan SCHEMBL8716118 | 0.85 | HTR1D (0.70) | HTR1DHTR1BHTR1AHTR1FHTR2A | |
| Naratriptan SCHEMBL68753 | 0.82 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR1FHTR6 | |
| Naratriptan SCHEMBL29403931 | 0.82 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR1FHTR6 | |
| Naratriptan SCHEMBL28587084 | 0.82 | HTR1D (0.98) | HTR1DHTR1BHTR1AHTR1FHTR6 | |
| Naratriptan SCHEMBL41527 | 0.82 | HTR1D (0.98) | HTR1DHTR1BHTR1AHTR1FHTR6 | |
| Naratriptan SCHEMBL12803311 | 0.82 | HTR1D (0.98) | HTR1DHTR1BHTR1AHTR1FHTR6 | |
| Naratriptan SCHEMBL30903899 | 0.82 | HTR1D (0.98) | HTR1DHTR1BHTR1AHTR1FHTR6 | |
| Naratriptan SCHEMBL41528 | 0.81 | HTR1D (0.96) | HTR1DHTR1BHTR1AHTR1FHTR6 | |
| Naratriptan SCHEMBL8716115 | 0.80 | HTR1D (0.69) | HTR1DHTR1BHTR1AHTR1FHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5705506-A | TREATMENT OF MIGRAINES OR HEADACHES | LABORATOIRES GLAXO SA (FR) | 1998-01-06 | — | — | US | claimed |