SCHEMBL7865358

SCHEMBL7865358

CC(C)(C)C(=O)Nc1ccc(CCCC(=O)O)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR1H4 Q96RI1 2/20 0.64
L3MBTL1 Q9Y468 1/20 0.59
HSD17B10 Q99714 1/20 0.53
HDAC3 O15379 2/20 0.51
HDAC4 P56524 2/20 0.51
HDAC1 Q13547 2/20 0.51
HDAC7 Q8WUI4 2/20 0.51
HDAC2 Q92769 2/20 0.51
HDAC10 Q969S8 2/20 0.51
HDAC11 Q96DB2 2/20 0.51
HDAC8 Q9BY41 2/20 0.51
HDAC6 Q9UBN7 2/20 0.51
HDAC9 Q9UKV0 2/20 0.51
HDAC5 Q9UQL6 2/20 0.51
SMN1; SMN2 Q16637 2/20 0.51
MAPK1 P28482 1/20 0.51
ADRA1A P35348 1/20 0.51
SLC6A3 Q01959 1/20 0.51
FFAR1 O14842 2/20 0.50
EPHX2 P34913 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL547352 0.84 NR1H4 (0.57) NR1H4HSD17B10HDAC3HDAC4HDAC1
SCHEMBL12319239 0.84 NPC1 (0.68) L3MBTL1SMN1; SMN2NPC1HPGDRAB9A
SCHEMBL5366230 0.82 HSD17B10 (0.62) NR1H4L3MBTL1HSD17B10HDAC3HDAC4
SCHEMBL15295162 0.82 SMN1; SMN2 (0.60) NR1H4HSD17B10HDAC3HDAC4HDAC1
SCHEMBL15503323 0.81 SPHK1 (0.63) L3MBTL1S1PR1NPC1HPGDRAB9A
SCHEMBL29037524 0.81 SPHK1 (0.63) L3MBTL1S1PR1NPC1HPGDRAB9A
SCHEMBL28701516 0.81 SPHK1 (0.63) L3MBTL1S1PR1NPC1HPGDRAB9A
SCHEMBL3569934 0.81 NR1H4 (0.60) NR1H4HSD17B10HDAC3HDAC4HDAC1
SCHEMBL12321314 0.80 L3MBTL1 (0.68) L3MBTL1HDAC3HDAC4HDAC1HDAC7
SCHEMBL2611230 0.79 L3MBTL1 (0.66) L3MBTL1HDAC3HDAC4HDAC1HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6316490-B1 FOR THERAPY OF PARKINSON'S DISEASE, ALZHEIMER'S DISEASE, DEMENTIA, CONTROLLING PAIN MERCK & CO., INC. 2001-11-13 US disclosed
EP-0874818-A1 NOVEL SUBSTITUTED ARYL COMPOUNDS USEFUL AS MODULATORS OF ACETYLCHOLINE RECEPTORS SIBIA NEUROSCIENCES, INC. (US) 1998-11-04 EP disclosed
WO-1997019059-A1 NOVEL SUBSTITUTED ARYL COMPOUNDS USEFUL AS MODULATORS OF ACETYLCHOLINE RECEPTORS SIBIA NEUROSCIENCES, INC. (US) 1997-05-29 WO disclosed