Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Homidium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 7/20 | 0.63 |
| ▸ | MEN1 | O00255 | 5/20 | 0.94 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.94 |
| ▸ | MAPT | P10636 | 5/20 | 0.94 |
| ▸ | BLM | P54132 | 4/20 | 0.94 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.94 |
| ▸ | HPGD | P15428 | 4/20 | 0.94 |
| ▸ | HTT | P42858 | 4/20 | 0.94 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.94 |
| ▸ | THRB | P10828 | 3/20 | 0.94 |
| ▸ | CASP1 | P29466 | 3/20 | 0.94 |
| ▸ | RECQL | P46063 | 3/20 | 0.94 |
| ▸ | CASP7 | P55210 | 3/20 | 0.94 |
| ▸ | TERT | O14746 | 3/20 | 0.94 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.94 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.94 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.94 |
| ▸ | MITF | O75030 | 2/20 | 0.94 |
| ▸ | NSD2 | O96028 | 2/20 | 0.94 |
| ▸ | LMNA | P02545 | 2/20 | 0.94 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Homidium SCHEMBL11023665 | 0.99 | MEN1 (0.97) | MEN1KMT2AMAPTBLMKDM4E | |
| Homidium SCHEMBL4354124 | 0.99 | MEN1 (0.97) | MEN1KMT2AMAPTBLMKDM4E | |
| Homidium SCHEMBL8777149 | 0.97 | MEN1 (0.97) | MEN1KMT2AMAPTBLMKDM4E | |
| Homidium SCHEMBL17460393 | 0.97 | MEN1 (0.94) | MEN1KMT2AMAPTBLMKDM4E | |
| Homidium SCHEMBL29391335 | 0.97 | MEN1 (1.00) | MEN1KMT2AMAPTBLMKDM4E | |
| Homidium SCHEMBL27609 | 0.97 | MEN1 (1.00) | MEN1KMT2AMAPTBLMKDM4E | |
| Homidium SCHEMBL21647365 | 0.97 | MEN1 (1.00) | MEN1KMT2AMAPTBLMKDM4E | |
| Homidium SCHEMBL31511751 | 0.97 | MEN1 (1.00) | MEN1KMT2AMAPTBLMKDM4E | |
| Homidium SCHEMBL7751164 | 0.96 | MEN1 (1.00) | MEN1KMT2AMAPTBLMKDM4E | |
| Homidium SCHEMBL19690770 | 0.96 | MEN1 (0.97) | MEN1KMT2AMAPTBLMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316195-B1 | OLIGONUCLEOTIDE PRIMER FOR USE IN DETECTING PREFERENTIAL PARASITE NUCLEOTIDE SEQUENCES IN SAMPLE | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE | 2001-11-13 | — | — | US | disclosed |
| US-6068843-A | AN AMOUNT OF A 56 KDA POLYPEPTIDE ENCODED BY A 2.3 KB HINDIII PARTIAL DIGEST RESTRICTION FRAGMENT OF SERPULINA HYODYSENTERIAE B204 EFFECTIVE TO PRODUCE A PROTECTIVE IMMUNE RESPONE AGAINST SERPULINA HYODYSENTERIE INFECTION IN SWINE | BOARD OF REGENTS UNIVERSITY OF NEBRASKA (US) | 2000-05-30 | — | — | US | disclosed |
| US-5869630-A | ISOLATED HINDIII RESTRICTION ENZYME DNA FRAGMENT, 2.3KB FROM CHROMOSOMAL DNA OF BACTERIA CAUSING SWINE DIARRHEA FOR DETECTION KIT WITH AMPLIFICATION PRIMERS AND HYBRIDIZATION PROBES; IMMUNIZATION, VACCINES AND MONITORING OF ANIMALS | BOARD OF REGENTS, UNIVERSITY OF NEBRASKA LINCOLN (US) | 1999-02-09 | — | — | US | disclosed |
| US-5698394-A | AMPLIFICATION OF TARGET DNA SEQUENCE BY POLYMERASE CHAIN REACTION USING ATLEAST ONE PRIMER THAT HYBRIDIZE TO TARGET SEQUENCE | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 1997-12-16 | — | — | US | disclosed |