Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.86 |
| ▸ | TSHR | P16473 | 5/20 | 0.86 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.31 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alcohol SCHEMBL28402873 | 1.00 | ALDH1A1 (0.86) | ALDH1A1TSHRSMN1; SMN2LMNAHSD17B10 | |
| Alcohol SCHEMBL452225 | 1.00 | — | — | |
| Alcohol SCHEMBL15348581 | 1.00 | ALDH1A1 (0.86) | ALDH1A1TSHRSMN1; SMN2LMNAHSD17B10 | |
| Alcohol SCHEMBL28515749 | 1.00 | ALDH1A1 (0.86) | ALDH1A1TSHRSMN1; SMN2LMNAHSD17B10 | |
| Alcohol SCHEMBL449296 | 1.00 | — | — | |
| Alcohol SCHEMBL4485375 | 1.00 | — | — | |
| Alcohol SCHEMBL5314318 | 1.00 | ALDH1A1 (0.86) | ALDH1A1TSHRSMN1; SMN2LMNAHSD17B10 | |
| Alcohol SCHEMBL175188 | 1.00 | — | — | |
| Alcohol SCHEMBL9815312 | 1.00 | — | — | |
| Alcohol SCHEMBL9225033 | 1.00 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107974-A4 | NOVEL HYDRATE FORMS OF ALENDRONATE SODIUM, PROCESSES FOR MANUFACTURE THEREOF, AND PHARMACEUTICAL COMPOSITIONS THEREOF | TEVA PHARMA (IL) | 2001-09-26 | — | — | EP | disclosed |
| EP-1107974-A1 | NOVEL HYDRATE FORMS OF ALENDRONATE SODIUM, PROCESSES FOR MANUFACTURE THEREOF, AND PHARMACEUTICAL COMPOSITIONS THEREOF | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012517-A9 | NOVEL HYDRATE FORMS OF ALENDRONATE SODIUM, PROCESSES FOR MANUFACTURE THEREOF, AND PHARMACEUTICAL COMPOSITIONS THEREOF | TEVA PHARMA (IL) | 2000-07-13 | — | — | WO | disclosed |
| WO-2000012517-A1 | NOVEL HYDRATE FORMS OF ALENDRONATE SODIUM, PROCESSES FOR MANUFACTURE THEREOF, AND PHARMACEUTICAL COMPOSITIONS THEREOF | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2000-03-09 | — | — | WO | disclosed |