Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 1/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.49 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.49 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.49 |
| ▸ | F2 | P00734 | 2/20 | 0.48 |
| ▸ | PLG | P00747 | 2/20 | 0.48 |
| ▸ | C1S | P09871 | 1/20 | 0.48 |
| ▸ | PLAU | P00749 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | PLAT | P00750 | 1/20 | 0.46 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1436168 | 0.86 | ALDH1A1 (0.59) | MEN1KMT2AALDH1A1 | |
| SCHEMBL7875123 | 0.86 | PARP1 (0.60) | MEN1KMT2AALDH1A1 | |
| SCHEMBL10671451 | 0.85 | PRSS1 (0.52) | NOS1PRSS1PRSS2PRSS3F2 | |
| Hydrochloric Acid SCHEMBL3576551 | 0.84 | ALDH1A1 (0.57) | PLAUMEN1KMT2AALDH1A1 | |
| SCHEMBL7877536 | 0.83 | KMT2A (0.66) | MEN1KMT2AALDH1A1 | |
| SCHEMBL7865767 | 0.82 | POLB (0.47) | MEN1KMT2AALDH1A1 | |
| SCHEMBL12348392 | 0.82 | MEN1 (0.59) | PRSS1PRSS2PRSS3F2PLAU | |
| SCHEMBL14169114 | 0.82 | TDP1 (0.46) | NOS1PRSS1PRSS2PRSS3F2 | |
| Amicarbalide SCHEMBL1818799 | 0.81 | PLAU (0.65) | PRSS1PRSS2PRSS3F2PLG | |
| SCHEMBL10177622 | 0.81 | PRSS1 (0.52) | NOS1PRSS1PRSS2PRSS3F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE37438-E1 | Acetamidine derivatives and their use as inhibitors for the nitric oxide synthase | GLAXO WELLCOME INC. | 2001-11-06 | — | — | US | disclosed |
| US-5866612-A | Acetamidine derivatives and their use as inhibitors for the nitric oxide synthase | GLAXO WELLCOME INC. (US) | 1999-02-02 | — | — | US | disclosed |
| EP-0799191-A1 | ACETAMIDINE DERIVATIVES AND THEIR USE AS INHIBITORS FOR THE NITRIC OXIDE SYNTHASE | THE WELLCOME FOUNDATION LIMITED (GB) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996019440-A1 | ACETAMIDINE DERIVATIVES AND THEIR USE AS INHIBITORS FOR THE NITRIC OXIDE SYNTHASE | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-06-27 | — | — | WO | disclosed |