Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | DHODH | Q02127 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18808346 | 0.83 | EGFR (0.63) | KMT2AMEN1DHODHMAPTSMN1; SMN2 | |
| SCHEMBL30716356 | 0.82 | KMT2A (0.58) | KMT2AMEN1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL1817688 | 0.82 | RAB9A (0.64) | KMT2AMEN1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL9312293 | 0.80 | MEN1 (0.73) | KMT2AMEN1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL7868204 | 0.80 | RAB9A (0.64) | KMT2AMEN1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL10363363 | 0.80 | CYP1A2 (0.58) | KMT2AMEN1DHODHMAPTSMN1; SMN2 | |
| SCHEMBL30764078 | 0.80 | LPAR2 (0.71) | KMT2ADHODHMAPTSMN1; SMN2HDAC3 | |
| SCHEMBL7438063 | 0.80 | CYP1A2 (0.58) | KMT2AMEN1DHODHMAPTSMN1; SMN2 | |
| SCHEMBL8996654 | 0.80 | MAPT (0.64) | KMT2AMEN1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL4319038 | 0.80 | MAPT (0.64) | KMT2AMEN1MAPTSMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129467-A1 | COMPOUNDS AND METHODS FOR INHIBITION OF RENIN, AND INDICATIONS THEREFOR | PLEXXIKON, INC. (US) | 2010-11-11 | — | — | WO | disclosed |
| US-5371226-A | Hypotensive agents | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1994-12-06 | — | — | US | disclosed |
| EP-0561252-A1 | 2-Oxoquinoline derivatives as angiotensin II antagonists | MERCK PATENT GmbH (DE) | 1993-09-22 | — | — | EP | disclosed |