SCHEMBL7866485

SCHEMBL7866485

CC(C)Nc1cccnc1N1CCN(C(=O)c2ccc(C(=O)N(C)CCCN(C)C)cn2)CC1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA2A P08913 1/20 0.43
ADORA3 P0DMS8 1/20 0.43
CHRM1 P11229 1/20 0.43
MAOA P21397 1/20 0.43
TBXA2R P21731 1/20 0.43
OPRM1 P35372 1/20 0.43
MDH1 P40925 1/20 0.43
KCNH2 Q12809 1/20 0.43
ABCG2 Q9UNQ0 1/20 0.43
PRMT5 O14744 3/20 0.36
PRKAA2 P54646 3/20 0.36
PRKAB2 O43741 2/20 0.36
PRKAG1 P54619 2/20 0.36
PRKAA1 Q13131 2/20 0.36
PRKAG3 Q9UGI9 2/20 0.36
PRKAG2 Q9UGJ0 2/20 0.36
PRKAB1 Q9Y478 2/20 0.36
L3MBTL3 Q96JM7 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
TDP1 Q9NUW8 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7868124 0.92 ADRA2A (0.44) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL8709879 0.91 ADRA2A (0.46) ADRA2AADORA3CHRM1MAOATBXA2R
Hydrochloric Acid SCHEMBL7861439 0.86 ADRA2A (0.44) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL7866450 0.85 ADRA2A (0.44) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL7861547 0.85 ADRA2A (0.47) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL7873115 0.85 ADRA2A (0.42) ADRA2AADORA3CHRM1MAOATBXA2R
Hydrochloric Acid SCHEMBL7861562 0.85 ADRA2A (0.42) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL8714403 0.85 ADRA2A (0.47) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL7869792 0.83 ADRA2A (0.43) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL7866488 0.83 ADRA2A (0.49) ADRA2AADORA3CHRM1MAOATBXA2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6306860-B1 ANTIVIRAL ACTIVITIES AGAINST HEPATATIS B AS WELL AS HUMAN IMMUNODEFICIENCY VIRUS DONG WHA PHARM. INC. CO., LTD. (KR) 2001-10-23 US disclosed
WO-1999058526-A1 NOVEL 2,5-PYRIDINEDICARBOXYLIC ACID DERIVATIVES DONG WHA PHARM. IND. CO., LTD. (KR) 1999-11-18 WO disclosed