Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.33 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4935075 | 0.75 | — | — | |
| SCHEMBL10506774 | 0.72 | — | — | |
| SCHEMBL11623926 | 0.69 | — | — | |
| Water SCHEMBL28435541 | 0.67 | CYP1A2 (0.36) | RAB9ANPC1L3MBTL1TDP1CYP1A2 | |
| SCHEMBL9975308 | 0.65 | RAB9A (0.42) | RAB9ANPC1L3MBTL1TDP1ALDH1A1 | |
| SCHEMBL1069 | 0.65 | — | — | |
| SCHEMBL577198 | 0.65 | CYP1A2 (0.47) | TDP1ALDH1A1CYP1A2MAPTKMT2A | |
| SCHEMBL8629808 | 0.65 | — | — | |
| SCHEMBL7571225 | 0.65 | CYP1A2 (0.47) | TDP1ALDH1A1CYP1A2MAPTKMT2A | |
| SCHEMBL151183 | 0.65 | CYP1A2 (0.47) | TDP1ALDH1A1CYP1A2MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418099-B1 | Process of preparation of 10, 11-Methylenedioxy-20 (RS) camptothecin and 10, 11-methylenedioxy-20 (S) - camptothecin analog | RES TRIANGLE INST (US) | 2001-12-19 | — | — | EP | disclosed |
| US-5340817-A | Method of treating tumors with anti-tumor effective camptothecin compounds | RESEARCH TRIANGLE INSTITUTE (US) | 1994-08-23 | — | — | US | disclosed |
| US-5180722-A | Topisomerase Inhibitors, Anticarcinogenic Agents | RESEARCH TRIANGLE INSTITUTE (US) | 1993-01-19 | — | — | US | disclosed |
| EP-0418099-A2 | 10, 11-Methylenedioxy-20 (RS) camptothecin and 10, 11-methylenedioxy-20 (S) - camptothecin analog | RESEARCH TRIANGLE INSTITUTE (US) | 1991-03-20 | — | — | EP | disclosed |