Olomoucine Ii

Olomoucine Ii

SCHEMBL786673

CC[C@H](CO)Nc1nc(NCc2ccccc2O)c2ncn(C(C)C)c2n1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 16/20 1.00
CCNE1 P24864 14/20 1.00
CDK1 P06493 10/20 1.00
CDK9 P50750 8/20 1.00
CCNB1 P14635 8/20 1.00
CDK5 Q00535 7/20 1.00
CCNT1 O60563 6/20 1.00
CCNB2 O95067 6/20 1.00
CCNB3 Q8WWL7 6/20 1.00
CDK5R1 Q15078 5/20 1.00
CACNA1B Q00975 2/20 1.00
CCNE2 O96020 3/20 0.79
CCNT2 O60583 1/20 0.79
CDK7 P50613 5/20 0.78
CDK4 P11802 3/20 0.78
CCND1 P24385 3/20 0.78
MAPK1 P28482 3/20 0.78
CCNH P51946 3/20 0.78
CCNK O75909 3/20 0.78
CDK12 Q9NYV4 3/20 0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Olomoucine Ii SCHEMBL31069520 1.00 CDK2 (1.00) CDK2CCNE1CDK1CDK9CCNB1
Olomoucine Ii SCHEMBL3514137 1.00 CDK2 (1.00) CDK2CCNE1CDK1CDK9CCNB1
SCHEMBL1352423 0.90 CDK2 (0.81) CDK2CCNE1CDK1CDK9CCNB1
SCHEMBL15117753 0.88 CDK2 (0.80) CDK2CCNE1CDK1CDK9CCNB1
SCHEMBL1441193 0.88 CDK2 (0.85) CDK2CCNE1CDK1CDK9CCNB1
SCHEMBL15118130 0.88 CDK2 (1.00) CDK2CCNE1CDK1CDK9CCNB1
(Rs)-Roscovitine SCHEMBL172593 0.87 CDK1 (1.00) CDK2CCNE1CDK1CDK9CCNB1
(S)-Roscovitine SCHEMBL2907488 0.87 CDK1 (1.00) CDK2CCNE1CDK1CDK9CCNB1
Seliciclib SCHEMBL94728 0.87 CDK1 (1.00) CDK2CCNE1CDK1CDK9CCNB1
(Rs)-Roscovitine SCHEMBL15163619 0.87 CDK1 (1.00) CDK2CCNE1CDK1CDK9CCNB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 170 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118403163-A Medical application and pharmaceutical composition of PIN1/CDK1-pVHL signal path interfering agent 暨南大学 2024-07-30 CN claimed
US-20240009205-A1 THERAPEUTIC COMBINATION FOR THE TREATMENT OF BREAST CANCER IFOM -FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE (37%) (IT) 2024-01-11 US claimed
EP-4157246-A1 THERAPEUTIC COMBINATION FOR THE TREATMENT OF BREAST CANCER Fondazione Istituto Firc Di Oncologia Molecolare (IFOM) (IT) 2023-04-05 EP claimed
US-20230080670-A1 METHODS AND COMPOSITIONS FOR TREATING TUMORS USING TRANSCRIPTION INHIBITION AND DNA DAMAGE NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2023-03-16 US claimed
CN-115400213-A Medical application and pharmaceutical composition of CDK1-USP29-Twist1 signal channel down-regulator 暨南大学 2022-11-29 CN claimed
US-11452716-B2 Pharmaceutical composition and use thereof ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) 2022-09-27 US claimed
WO-2021214119-A1 THERAPEUTIC COMBINATION FOR THE TREATMENT OF BREAST CANCER IFOM - FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE (IT) 2021-10-28 WO claimed
US-20210275522-A1 PHARMACEUTICAL COMPOSITIONS AND USE THEREOF ASCENTAGE PHARMA SUZHOU CO LTD (CN) 2021-09-09 US claimed
US-10987356-B2 Dual inhibition of CDK and HSP90 destabilize H1F1 α and synergistically induces cancer cell death INSTITUTE FOR CANCER RESEARCH (US) 2021-04-27 US claimed
US-20200297704-A1 NOVEL PHARMACEUTICAL COMPOSITION AND USE THEREOF ASCENTAGE PHARMA GROUP CORP LIMITED (CN) 2020-09-24 US claimed
EP-3706741-A1 PHARMACEUTICAL COMPOSITION AND USE THEREOF Ascentage Pharma (Suzhou) Co., Ltd. (CN) 2020-09-16 EP claimed
EP-3697411-A1 NOVEL PHARMACEUTICAL COMPOSITION AND USE THEREOF Ascentage Pharma Group Corp Limited (CN) 2020-08-26 EP claimed
US-10729692-B2 Dual inhibition of CDK and HSP90 destabilize HIF1alpha and synergistically induces cancer cell death INSTITUTE FOR CANCER RESEARCH (US) 2020-08-04 US claimed
CN-111214471-A Pharmaceutical composition and use thereof 苏州亚盛药业有限公司 2020-06-02 CN claimed
US-20200155554-A1 Dual Inhibition Of CDK And HSP90 Destabilize H1F1alpha And Synergistically Induces Cancer Cell Death INSTITUTE FOR CANCER RESEARCH D/B/A THE RESEARCH INSTITUTE OF FOX CHASE CANCER CENTER 2020-05-21 US claimed
US-20180243306-A1 Dual Inhibition Of CDK And HSP90 Destabilize HIF1alpha And Synergistically Induces Cancer Cell Death INSTITUTE FOR CANCER RESEARCH D/B/A THE RESEARCH INSTITUTE OF FOX CHASE CANCER CENTER 2018-08-30 US claimed
WO-2013071415-A1 TARGETING THE RB PATHWAY FOR THE PREVENTION OF CANCER UNIVERSITY HEALTH NETWORK (CA) 2013-05-23 WO claimed
US-20260053799-A1 COMPOUNDS FOR TREATING CANCER EVEXTA BIO (FR) 2026-02-26 US disclosed
WO-2008021210-A2 METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS COMBINATORX, INCORPORATED (US) 2008-02-21 WO disclosed
US-20080044390-A1 Methods and compositions for the treatment of neurodegenerative disorders CHDI, INCORPORATED 2008-02-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260053799-A1 COMPOUNDS FOR TREATING CANCER NCOA1, AR, ESR2 CDK2 1129/4885CCNE1 1063/4885CDK1 949/4885
US-20210275522-A1 PHARMACEUTICAL COMPOSITIONS AND USE THEREOF CDK2, CDK5, CDK6 CDK2 1/4885CCNE1 89/4885CDK1 10/4885
US-20200297704-A1 NOVEL PHARMACEUTICAL COMPOSITION AND USE THEREOF TP53, CDK2, RB1 CDK2 2/4885CCNE1 53/4885CDK1 8/4885
US-11452716-B2 Pharmaceutical composition and use thereof TP53, RB1, CDK20 CDK2 4/4885CCNE1 55/4885CDK1 12/4885
US-20080044390-A1 Methods and compositions for the treatment of neurodegenerative disorders HTT, SNCA, NLN CDK2 3817/4885CCNE1 4860/4885CDK1 3289/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.