Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 9/20 | 0.58 |
| ▸ | CDC7 | O00311 | 8/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.58 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | JUN | P05412 | 1/20 | 0.42 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | PRKCG | P05129 | 1/20 | 0.39 |
| ▸ | PRKCB | P05771 | 1/20 | 0.39 |
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | PRKACG | P22612 | 1/20 | 0.39 |
| ▸ | PRKACB | P22694 | 1/20 | 0.39 |
| ▸ | PRKCH | P24723 | 1/20 | 0.39 |
| ▸ | PRKCI | P41743 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7022083 | 0.79 | ROCK1 (0.59) | ROCK1MKNK1MKNK2 | |
| SCHEMBL19533417 | 0.77 | CDK2 (0.67) | CDK2CDC7ROCK1MKNK1MAPK8 | |
| SCHEMBL3823223 | 0.76 | CDK1 (0.53) | CDK2MKNK1MAPK8MAPK9MKNK2 | |
| SCHEMBL6301371 | 0.75 | KDR (0.55) | — | |
| SCHEMBL5102168 | 0.75 | CDK2 (0.63) | CDK2CDC7ROCK1MKNK1MAPK8 | |
| SCHEMBL5659028 | 0.74 | RPS6KA5 (0.68) | CDK2CDC7ROCK1MKNK1MAPK8 | |
| SCHEMBL30753972 | 0.74 | CDC7 (1.00) | CDK2CDC7ROCK1MAP3K14 | |
| SCHEMBL9377410 | 0.74 | CDC7 (1.00) | CDK2CDC7ROCK1MAP3K14 | |
| SCHEMBL30459871 | 0.74 | RPS6KA5 (0.68) | CDK2CDC7ROCK1MKNK1MAPK8 | |
| SCHEMBL17918815 | 0.73 | BRAF (0.38) | ROCK1MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316444-B1 | SRC kinase inhibitor compounds | MERCK & CO., INC. | 2001-11-13 | — | — | US | disclosed |