Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SMYD2 | Q9NRG4 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29598613 | 0.83 | SMYD2 (0.35) | CYP3A4HTTSMN1; SMN2SMYD2 | |
| SCHEMBL7868266 | 0.81 | SMYD2 (0.32) | CYP3A4HTTSMN1; SMN2SMYD2 | |
| SCHEMBL19197241 | 0.81 | SMYD2 (0.38) | CYP3A4HTTSMN1; SMN2SMYD2 | |
| SCHEMBL23120682 | 0.79 | ALDH1A1 (0.36) | CYP3A4HTTSMN1; SMN2SMYD2 | |
| SCHEMBL19284859 | 0.79 | SMYD2 (0.33) | CYP3A4HTTSMN1; SMN2SMYD2 | |
| SCHEMBL19284858 | 0.79 | SMYD2 (0.33) | CYP3A4HTTSMN1; SMN2SMYD2 | |
| SCHEMBL7869179 | 0.77 | CYP3A4 (0.35) | CYP3A4HTTSMN1; SMN2SMYD2 | |
| SCHEMBL22750792 | 0.76 | KDM4E (0.40) | CYP3A4HTTSMN1; SMN2SMYD2 | |
| SCHEMBL17315963 | 0.76 | CYP3A4 (0.32) | CYP3A4HTTSMN1; SMN2 | |
| SCHEMBL19469982 | 0.76 | CYP3A4 (0.32) | CYP3A4HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657458-B1 | Protein kinase C inhibitors | LILLY CO ELI (US) | 2001-08-22 | — | — | EP | disclosed |
| US-6057440-A | AMINATION AND DEETHERIFICATION OF BISINDOLE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2000-05-02 | — | — | US | disclosed |
| US-5843935-A | Protein kinase C inhibitors | ELI LILLY AND COMPANY (US) | 1998-12-01 | — | — | US | disclosed |
| US-5821365-A | COMPOUNDS AS ENZYME INHIBITORS FOR KINASES FORMED BY REACTION OF AMINE WITH ANHYDRIDE GROUP TO FORM INDOLMALEIMIDE MACROCYCLES | ELI LILLY AND COMPANY (US) | 1998-10-13 | — | — | US | disclosed |
| US-5780461-A | ANTITUMOR AGENTS | ELI LILLY AND COMPANY (US) | 1998-07-14 | — | — | US | disclosed |
| US-5739322-A | INHIBITORS OF PROTEIN KINASE C IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-04-14 | — | — | US | disclosed |
| US-5719175-A | ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1998-02-17 | — | — | US | disclosed |
| US-5698578-A | BIS-INDOLEMALEIMIDE MACROCYCLE DERIVATIVES; TREATMENT OF DIABETES | ELI LILLY AND COMPANY (US) | 1997-12-16 | — | — | US | disclosed |
| US-5696108-A | ADMINISERING TO THE MAMMAL BIS-INDOLEMALEIMIDE MACROCYCLIC DERIVATIVE AS ANTIINFLAMMATORY AGENT | ELI LILLY AND COMPANY (US) | 1997-12-09 | — | — | US | disclosed |
| US-5674862-A | USING A BIS(INDOLEMALEIMIDE) MACROCYCLE DERIVATIVE | ELI LILLY AND COMPANY (US) | 1997-10-07 | — | — | US | disclosed |
| US-5624949-A | Protein kinase C inhibitors | ELI LILLY AND COMPANY (US) | 1997-04-29 | — | — | US | disclosed |
| US-5621098-A | ALKYLATION OF THE CORRESPONDING BISINDOLE COMPOUND; CYCLIZATION; PROTEIN C KINEASE INHIBITOR | ELI LILLY AND COMPANY (US) | 1997-04-15 | — | — | US | disclosed |
| US-5552396-A | BIS-INDOLEMALEIMIDE MACROCYCLIC DERIVATIVES, | ELI LILLY AND COMPANY (US) | 1996-09-03 | — | — | US | disclosed |
| EP-0657458-A1 | Protein kinase C inhibitors | ELI LILLY AND COMPANY (US) | 1995-06-14 | — | — | EP | disclosed |