SCHEMBL7868448

SCHEMBL7868448

Clc1ccc(COCC2CCN(CC3CN(Cc4ccc(Cl)cc4Cl)CC3c3ccsc3)CC2)c(Cl)c1

nearest known ligand 0.42

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CCR5 P51681 5/20 0.42
KDM4E B2RXH2 2/20 0.37
TDP1 Q9NUW8 2/20 0.37
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
CYP2A13 Q16696 1/20 0.34
ALDH1A1 P00352 1/20 0.34
POLB P06746 1/20 0.34
SIGMAR1 Q99720 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7868450 1.00 CCR5 (0.42) CCR5KDM4ETDP1MEN1KMT2A
SCHEMBL7869855 0.96 CCR5 (0.42) CCR5MEN1KMT2AALDH1A1SIGMAR1
SCHEMBL7869856 0.96 CCR5 (0.42) CCR5MEN1KMT2AALDH1A1SIGMAR1
SCHEMBL7521940 0.95 CCR5 (0.43) CCR5KDM4ETDP1MEN1KMT2A
SCHEMBL7521934 0.95 CCR5 (0.43) CCR5KDM4ETDP1MEN1KMT2A
SCHEMBL7863310 0.94 CCR5 (0.42) CCR5KDM4ETDP1
SCHEMBL7863308 0.94 CCR5 (0.42) CCR5KDM4ETDP1
SCHEMBL7519658 0.93 CCR5 (0.42) CCR5KDM4ETDP1MEN1KMT2A
SCHEMBL7519662 0.93 CCR5 (0.42) CCR5KDM4ETDP1MEN1KMT2A
SCHEMBL7863096 0.93 CCR5 (0.48) CCR5SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6303593-B1 FOR THERAPY HUMAN IMMUNODEFICIENCY VIRUS INFECTION, AQUIRED IMMUNODEFICIENCY SYNDROME (AIDS), INFLAMMATORY AND IMMUNOREGULATORY DISORDER OR DISEASE, ASTHMA, ALLERGIC RHINITIS, DERMATITIS, CONJUNCTIVITIS, ATHEROSCLEROSIS MERCK & CO., INC. 2001-10-16 US claimed
US-6303593-B1 FOR THERAPY HUMAN IMMUNODEFICIENCY VIRUS INFECTION, AQUIRED IMMUNODEFICIENCY SYNDROME (AIDS), INFLAMMATORY AND IMMUNOREGULATORY DISORDER OR DISEASE, ASTHMA, ALLERGIC RHINITIS, DERMATITIS, CONJUNCTIVITIS, ATHEROSCLEROSIS MERCK & CO., INC. 2001-10-16 US disclosed
WO-2000051608-A1 3-THIENYL AND 3-FURANYL PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 2000-09-08 WO disclosed