Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.36 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.34 |
| ▸ | HTR3B | O95264 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.34 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.34 |
| ▸ | STS | P08842 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7862514 | 0.76 | CHRM2 (0.35) | MEN1KMT2A | |
| SCHEMBL145605 | 0.73 | MEN1 (0.40) | KDM4EPKMMEN1KMT2ACARM1 | |
| SCHEMBL1912989 | 0.67 | MEN1 (0.62) | KDM4EPKMMEN1KMT2AUSP30 | |
| SCHEMBL14390228 | 0.67 | KDM4E (0.58) | KDM4EPKMMEN1KMT2AUSP30 | |
| SCHEMBL9382114 | 0.67 | KDM4E (0.58) | KDM4EPKMMEN1KMT2AUSP30 | |
| SCHEMBL5116359 | 0.67 | KDM4E (0.58) | KDM4EPKMMEN1KMT2AUSP30 | |
| SCHEMBL28057184 | 0.66 | KDM4E (0.48) | KDM4EPKMMEN1KMT2AUSP30 | |
| SCHEMBL23527089 | 0.65 | KDM4E (0.53) | KDM4EPKMMEN1KMT2AUSP30 | |
| SCHEMBL23527087 | 0.65 | KDM4E (0.53) | KDM4EPKMMEN1KMT2AUSP30 | |
| SCHEMBL19023294 | 0.65 | KDM4E (0.53) | KDM4EPKMMEN1KMT2AUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310095-B1 | INHIBITING OR TREATING CANCER, TREATING INTIMAL HYPERPLASIA ASSOCIATED WITH RESTENOSIS AND ATHEROSCLEROSIS, INHIBITING POST-TRANSLATIONAL MODIFICATION OF ONCOGENIC RAS PROTEIN BY PROTEIN FARNESYLTRANSFERASE AND/OR GERANYLGERANYLTRANSFERASE | UNIVERSITY OF PITTSBURGH | 2001-10-30 | — | — | US | disclosed |