Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | LTA4H | P09960 | 2/20 | 0.48 |
| ▸ | DPP4 | P27487 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3545 | 0.93 | L3MBTL1 (0.57) | L3MBTL1KDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL16291133 | 0.93 | L3MBTL1 (0.57) | L3MBTL1KDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL29776515 | 0.90 | L3MBTL1 (0.55) | L3MBTL1KDM4EALDH1A1MAPTMEN1 | |
| Hydrogen Sulfide SCHEMBL22588115 | 0.90 | L3MBTL1 (0.55) | L3MBTL1KDM4EALDH1A1MAPTMEN1 | |
| Benzene SCHEMBL28420098 | 0.90 | L3MBTL1 (0.55) | L3MBTL1KDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL30697256 | 0.90 | L3MBTL1 (0.55) | L3MBTL1KDM4EALDH1A1MAPTMEN1 | |
| Bromide SCHEMBL30467088 | 0.90 | L3MBTL1 (0.55) | L3MBTL1KDM4EALDH1A1MAPTMEN1 | |
| Fluoride SCHEMBL491501 | 0.90 | L3MBTL1 (0.55) | L3MBTL1KDM4EALDH1A1MAPTMEN1 | |
| Ammonia Solution, Strong SCHEMBL34467257 | 0.90 | L3MBTL1 (0.55) | L3MBTL1KDM4EALDH1A1MAPTMEN1 | |
| Bromide SCHEMBL29519314 | 0.90 | L3MBTL1 (0.55) | L3MBTL1KDM4EALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6312811-B1 | Photochromic naphtho [2,1-b]pyran compounds containing bithienyl or terthienyl substituents, process for their manufacture, and photochromic materials and articles obtained | ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) | 2001-11-06 | — | — | US | disclosed |