Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 11/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 10/20 | 0.45 |
| ▸ | GBA1 | P04062 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.42 |
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7869717 | 1.00 | SLC6A4 (0.45) | SLC6A4SLC6A2GBA1SLC6A3HRH1 | |
| SCHEMBL16056164 | 0.84 | SLC6A2 (0.47) | SLC6A4SLC6A2GBA1SLC6A3HRH1 | |
| SCHEMBL9978780 | 0.80 | GBA1 (0.47) | SLC6A4SLC6A2GBA1SLC6A3HRH1 | |
| SCHEMBL8969997 | 0.76 | GBA1 (0.47) | SLC6A4SLC6A2GBA1SLC6A3HRH1 | |
| SCHEMBL7875085 | 0.76 | GBA1 (0.47) | SLC6A4SLC6A2GBA1SLC6A3HRH1 | |
| SCHEMBL1475418 | 0.74 | SLC6A2 (0.47) | SLC6A4SLC6A2SLC6A3HTR1A | |
| SCHEMBL27536629 | 0.73 | CPN1 (0.53) | SLC6A4SLC6A2GBA1SLC6A3HRH1 | |
| SCHEMBL7863091 | 0.73 | SLC6A2 (0.47) | SLC6A4SLC6A2GBA1SLC6A3HRH1 | |
| SCHEMBL27939179 | 0.71 | SLC6A4 (0.42) | SLC6A4SLC6A2GBA1SLC6A3 | |
| SCHEMBL27526570 | 0.71 | GBA1 (0.45) | SLC6A4SLC6A2GBA1SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303593-B1 | FOR THERAPY HUMAN IMMUNODEFICIENCY VIRUS INFECTION, AQUIRED IMMUNODEFICIENCY SYNDROME (AIDS), INFLAMMATORY AND IMMUNOREGULATORY DISORDER OR DISEASE, ASTHMA, ALLERGIC RHINITIS, DERMATITIS, CONJUNCTIVITIS, ATHEROSCLEROSIS | MERCK & CO., INC. | 2001-10-16 | — | — | US | disclosed |