Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3832795 | 0.84 | SLC6A2 (0.47) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL22850604 | 0.83 | GBA1 (0.50) | GBA1SLC6A4SLC6A2SLC6A3HRH1 | |
| SCHEMBL16191445 | 0.83 | HTT (0.54) | — | |
| SCHEMBL7875085 | 0.80 | GBA1 (0.47) | GBA1SLC6A4SLC6A2SLC6A3HRH1 | |
| SCHEMBL8969997 | 0.80 | GBA1 (0.47) | GBA1SLC6A4SLC6A2SLC6A3HRH1 | |
| SCHEMBL7869711 | 0.80 | SLC6A4 (0.45) | GBA1SLC6A4SLC6A2SLC6A3HRH1 | |
| SCHEMBL7869717 | 0.80 | SLC6A4 (0.45) | GBA1SLC6A4SLC6A2SLC6A3HRH1 | |
| SCHEMBL5781115 | 0.77 | SLC6A4 (0.42) | GBA1SLC6A4SLC6A2SLC6A3HRH1 | |
| SCHEMBL27536629 | 0.76 | CPN1 (0.53) | GBA1SLC6A4SLC6A2SLC6A3HRH1 | |
| SCHEMBL21583639 | 0.75 | SIGMAR1 (0.43) | SLC6A4SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627650-A2 | N-PHENYL IMIDAZOLE CARBOXAMIDE INHIBITORS OF 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE-1 | Merck Sharp & Dohme Corp. (US) | 2013-08-21 | — | — | EP | disclosed |
| WO-2011149874-A2 | N-PHENYL IMIDAZOLE CARBOXAMIDE INHIBITORS OF 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE-1 | SCHERING CORPORATION (US) | 2011-12-01 | — | — | WO | disclosed |