Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 15/20 | 0.60 |
| ▸ | MMP1 | P03956 | 5/20 | 0.50 |
| ▸ | MMP2 | P08253 | 2/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 3/20 | 0.45 |
| ▸ | MMP3 | P08254 | 1/20 | 0.45 |
| ▸ | MMP14 | P50281 | 1/20 | 0.45 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.44 |
| ▸ | ANPEP | P15144 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7862189 | 0.88 | ATM (0.48) | MMP13MMP1MMP2ATMMMP9 | |
| SCHEMBL7181926 | 0.88 | MMP13 (0.75) | MMP13MMP1MMP2ADAM17MMP9 | |
| SCHEMBL7874056 | 0.87 | MMP13 (0.64) | MMP13MMP1MMP2ADAM17MMP9 | |
| SCHEMBL7867098 | 0.86 | MMP13 (0.58) | MMP13MMP1MMP2MMP9MMP3 | |
| SCHEMBL7197640 | 0.84 | MMP13 (0.60) | MMP13MMP1MMP2ADAM17MMP9 | |
| SCHEMBL7178057 | 0.83 | MMP13 (0.56) | MMP13MMP1MMP2ADAM17MMP9 | |
| Trifluoroacetic Acid SCHEMBL7862137 | 0.81 | MMP13 (0.52) | MMP13MMP1MMP2MMP9MMP3 | |
| Trifluoroacetic Acid SCHEMBL7870767 | 0.80 | MMP13 (0.55) | MMP13MMP1MMP2MMP9MMP3 | |
| SCHEMBL7868827 | 0.79 | MMP13 (0.78) | MMP13MMP1MMP2MMP9 | |
| SCHEMBL7181094 | 0.79 | MMP13 (0.70) | MMP13MMP1MMP2MMP9MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300514-B1 | INHIBITING MATRIX METALLOPROTEINASES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-10-09 | — | — | US | claimed |
| EP-0994104-A1 | ARYL (SULFIDE, SULFOXIDE AND SULFONE) DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-04-19 | — | — | EP | claimed |
| US-6300514-B1 | INHIBITING MATRIX METALLOPROTEINASES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-10-09 | — | — | US | disclosed |
| EP-0994104-A1 | ARYL (SULFIDE, SULFOXIDE AND SULFONE) DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-04-19 | — | — | EP | disclosed |