Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 20/20 | 0.75 |
| ▸ | RXRG | P48443 | 14/20 | 0.72 |
| ▸ | RXRB | P28702 | 13/20 | 0.72 |
| ▸ | RARA | P10276 | 4/20 | 0.59 |
| ▸ | RARB | P10826 | 4/20 | 0.59 |
| ▸ | RARG | P13631 | 4/20 | 0.59 |
| ▸ | PPARG | P37231 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.57 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.57 |
| ▸ | ESR1 | P03372 | 1/20 | 0.57 |
| ▸ | PGR | P06401 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.57 |
| ▸ | DRD1 | P21728 | 1/20 | 0.57 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6891059 | 1.00 | RXRA (0.75) | RXRARXRGRXRBRARARARB | |
| SCHEMBL6892115 | 0.88 | RXRA (0.73) | RXRARXRGRXRBRARARARB | |
| SCHEMBL7874373 | 0.88 | RXRA (0.73) | RXRARXRGRXRBRARARARB | |
| SCHEMBL726852 | 0.86 | RXRA (1.00) | RXRARXRGRXRBRARARARB | |
| SCHEMBL6890738 | 0.85 | RXRA (0.78) | RXRARXRGRXRBRARARARB | |
| SCHEMBL5534961 | 0.85 | RXRA (0.56) | RXRARXRGRXRBRARARARB | |
| SCHEMBL6888698 | 0.84 | RXRA (1.00) | RXRARXRGRXRBRARARARB | |
| SCHEMBL13752412 | 0.84 | RXRA (1.00) | RXRARXRGRXRBRARARARB | |
| SCHEMBL2685542 | 0.84 | RXRA (1.00) | RXRARXRGRXRBRARARARB | |
| SCHEMBL1073659 | 0.82 | RXRA (0.84) | RXRARXRGRXRBRARARARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6320074-B1 | IN VIVO MODULATION OF LIPID METABOLISM, SKIN-RELATED PROCESSES, AUTOIMMUNE DISEASES, FATTY ACID METABOLISM, MALIGNANT CELL DEVELOPMENT, PREMALIGNANT LESIONS, OR PROGRAMMED CELL DEATH | LIGAND PHARMACEUTICALS INCORPORATED | 2001-11-20 | — | — | US | claimed |
| EP-0678086-B1 | COMPOUNDS HAVING SELECTIVITY FOR RETINOID X RECEPTORS | LIGAND PHARM INC (US) | 1999-12-08 | — | — | EP | claimed |