Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 3/20 | 0.37 |
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7867694 | 0.90 | EPHX2 (0.43) | LMNACYP3A4HTR1AMAPTCYP2C9 | |
| SCHEMBL7870549 | 0.88 | MAPT (0.47) | LMNACYP3A4HTR1AMAPTCYP2C9 | |
| SCHEMBL7871341 | 0.86 | MAPT (0.46) | LMNACYP3A4HTR1AMAPTCYP2C9 | |
| SCHEMBL9018314 | 0.86 | MAPT (0.49) | LMNACYP3A4HTR1AMAPTCYP2C9 | |
| SCHEMBL7871673 | 0.86 | ACACB (0.43) | LMNAKMT2AMEN1EGFRCA1 | |
| SCHEMBL7862898 | 0.85 | LMNA (0.47) | LMNACYP3A4HTR1AMAPTCYP2C9 | |
| SCHEMBL7870460 | 0.84 | MAPT (0.44) | LMNACYP3A4HTR1AMAPTCYP2C9 | |
| SCHEMBL7867814 | 0.84 | MEN1 (0.48) | MAPTSMN1; SMN2KMT2AMEN1NPC1 | |
| SCHEMBL9018409 | 0.84 | MAPT (0.49) | LMNACYP3A4HTR1AMAPTCYP2C9 | |
| SCHEMBL7862712 | 0.83 | EGFR (0.51) | MAPTCYP2C19SMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |