Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.44 |
| ▸ | EP300 | Q09472 | 1/20 | 0.61 |
| ▸ | FNTA | P49354 | 1/20 | 0.44 |
| ▸ | FNTB | P49356 | 1/20 | 0.44 |
| ▸ | TERT | O14746 | 3/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.44 |
| ▸ | PPARG | P37231 | 3/20 | 0.44 |
| ▸ | PPARD | Q03181 | 3/20 | 0.44 |
| ▸ | PPARA | Q07869 | 3/20 | 0.44 |
| ▸ | TOP1 | P11387 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | FABP4 | P15090 | 2/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL7871722 | 1.00 | EP300 (0.61) | EP300FNTAFNTBTERTPTPN1 | |
| Iodide SCHEMBL7871644 | 1.00 | EP300 (0.61) | EP300FNTAFNTBTERTPTPN1 | |
| Iodide SCHEMBL7871646 | 1.00 | EP300 (0.61) | EP300FNTAFNTBTERTPTPN1 | |
| SCHEMBL21568 | 0.98 | EP300 (0.63) | EP300FNTAFNTBTERTPTPN1 | |
| SCHEMBL1126330 | 0.98 | EP300 (0.63) | EP300FNTAFNTBTERTPTPN1 | |
| SCHEMBL21570 | 0.98 | EP300 (0.63) | EP300FNTAFNTBTERTPTPN1 | |
| SCHEMBL166403 | 0.96 | EP300 (0.67) | EP300FNTAFNTBTERTPTPN1 | |
| SCHEMBL22151487 | 0.96 | EP300 (0.67) | EP300FNTAFNTBTERTPTPN1 | |
| SCHEMBL993468 | 0.96 | EP300 (0.67) | EP300FNTAFNTBTERTPTPN1 | |
| SCHEMBL22151496 | 0.96 | EP300 (0.67) | EP300FNTAFNTBTERTPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1090013-A1 | PROPENYL CEPHALOSPORIN DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-1999067255-A1 | PROPENYL CEPHALOSPORIN DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-12-29 | — | — | WO | disclosed |