Methidathion

Methidathion

SCHEMBL7871758

COc1nn(CSP(=S)(OC)OC)c(=O)s1.COc1nn(CSP(=S)(OC)OC)c(=O)s1

nearest known ligand 0.44

Full drug profile on Sugi Atlas →

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.44
MAPT P10636 3/20 0.44
HPGD P15428 2/20 0.44
ALOX15 P16050 2/20 0.44
KDM4E B2RXH2 1/20 0.44
LMNA P02545 1/20 0.44
CYP3A4 P08684 1/20 0.44
TSHR P16473 1/20 0.44
MAPK1 P28482 1/20 0.44
HSD17B10 Q99714 1/20 0.44
PLIN1 O60240 1/20 0.42
PLIN5 Q00G26 1/20 0.42
ABHD5 Q8WTS1 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methidathion SCHEMBL26675 1.00 ALDH1A1 (0.44) ALDH1A1MAPTHPGDALOX15KDM4E
SCHEMBL1069689 0.89 ALDH1A1 (0.37) ALDH1A1MAPTHPGDALOX15KDM4E
Methidathion SCHEMBL16859921 0.89 ALDH1A1 (0.37) ALDH1A1MAPTHPGDALOX15KDM4E
Methidathion SCHEMBL5264915 0.89 ALDH1A1 (0.37) ALDH1A1MAPTHPGDALOX15KDM4E
SCHEMBL116389 0.88 ALDH1A1 (0.42) ALDH1A1MAPTHPGDALOX15KDM4E
SCHEMBL7876087 0.88 ALDH1A1 (0.42) ALDH1A1MAPTHPGDALOX15KDM4E
SCHEMBL121376 0.87 MEN1 (0.37) ALDH1A1MAPTHPGDALOX15KDM4E
Methidathion SCHEMBL28173994 0.87 ALDH1A1 (0.38) ALDH1A1MAPTHPGDALOX15KDM4E
SCHEMBL3730801 0.86 KDM4E (0.32) ALDH1A1MAPTHPGDALOX15KDM4E
Methidathion SCHEMBL1068991 0.86 ALDH1A1 (0.35) ALDH1A1MAPTHPGDALOX15KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0564945-B1 A method of controlling harmful insects BAYER AGROCHEM KK (JP) 2001-01-24 EP disclosed
US-6063393-A RODS OR PINS TO BE PRESSED INTO PLANTS NIHON BAYER AGROCHEM K.K. (JP) 2000-05-16 US disclosed
US-5925676-A INSECICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1999-07-20 US disclosed
US-5354565-A Activation with a quaternary ammonium compound KAO CORPORATION (JP) 1994-10-11 US disclosed
EP-0564945-A1 A method of controlling harmful insects NIHON BAYER AGROCHEM K.K. (JP) 1993-10-13 EP disclosed