Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 18/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 17/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.64 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL556391 | 0.91 | REN (0.77) | RENKCNH2CYP3A4AKT1 | |
| SCHEMBL556392 | 0.91 | REN (0.77) | RENKCNH2CYP3A4AKT1 | |
| SCHEMBL557655 | 0.78 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL556580 | 0.77 | REN (0.49) | RENKCNH2CYP3A4AKT1 | |
| SCHEMBL556906 | 0.77 | REN (0.48) | RENKCNH2CYP3A4AKT1 | |
| SCHEMBL556907 | 0.77 | REN (0.48) | RENKCNH2CYP3A4AKT1 | |
| SCHEMBL7862962 | 0.77 | REN (0.84) | RENKCNH2CYP3A4 | |
| SCHEMBL557232 | 0.72 | REN (0.63) | RENKCNH2CYP3A4AKT1 | |
| SCHEMBL557233 | 0.69 | REN (0.64) | RENKCNH2CYP3A4AKT1 | |
| SCHEMBL555873 | 0.69 | REN (0.64) | RENKCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |