SCHEMBL7871891

SCHEMBL7871891

Fc1ccc(C2CCN(C[C@H]3CN(Cc4ccc(Cl)cc4)C[C@@H]3c3ccsc3)CC2)cc1

nearest known ligand 0.56

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CCR5 P51681 9/20 0.56
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45
DRD2 P14416 5/20 0.43
HTR1A P08908 3/20 0.43
HTR2A P28223 3/20 0.43
DRD3 P35462 3/20 0.43
DRD1 P21728 1/20 0.43
DRD5 P21918 1/20 0.43
DRD4 P21917 1/20 0.41
SLC18A3 Q16572 2/20 0.40
SIGMAR1 Q99720 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7869725 1.00 CCR5 (0.56) CCR5MEN1KMT2ADRD2HTR1A
SCHEMBL7874879 0.91 CCR5 (0.55) CCR5MEN1KMT2ASLC18A3SIGMAR1
SCHEMBL7872008 0.91 CCR5 (0.55) CCR5MEN1KMT2ASLC18A3SIGMAR1
SCHEMBL7872009 0.91 CCR5 (0.55) CCR5MEN1KMT2ASLC18A3SIGMAR1
SCHEMBL7868460 0.91 CCR5 (0.67) CCR5SLC18A3SIGMAR1
SCHEMBL7863366 0.91 CCR5 (0.67) CCR5SLC18A3SIGMAR1
SCHEMBL7871208 0.91 CCR5 (0.55) CCR5MEN1KMT2ASLC18A3SIGMAR1
SCHEMBL7871214 0.91 CCR5 (0.55) CCR5MEN1KMT2ASLC18A3SIGMAR1
SCHEMBL7863251 0.90 CCR5 (0.64) CCR5MEN1KMT2ADRD2DRD4
SCHEMBL7863249 0.90 CCR5 (0.64) CCR5MEN1KMT2ADRD2DRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6303593-B1 FOR THERAPY HUMAN IMMUNODEFICIENCY VIRUS INFECTION, AQUIRED IMMUNODEFICIENCY SYNDROME (AIDS), INFLAMMATORY AND IMMUNOREGULATORY DISORDER OR DISEASE, ASTHMA, ALLERGIC RHINITIS, DERMATITIS, CONJUNCTIVITIS, ATHEROSCLEROSIS MERCK & CO., INC. 2001-10-16 US claimed
US-6303593-B1 FOR THERAPY HUMAN IMMUNODEFICIENCY VIRUS INFECTION, AQUIRED IMMUNODEFICIENCY SYNDROME (AIDS), INFLAMMATORY AND IMMUNOREGULATORY DISORDER OR DISEASE, ASTHMA, ALLERGIC RHINITIS, DERMATITIS, CONJUNCTIVITIS, ATHEROSCLEROSIS MERCK & CO., INC. 2001-10-16 US disclosed