Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 8/20 | 0.63 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.50 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.45 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.45 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | GCK | P35557 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3387141 | 0.79 | KIT (0.56) | MTORLRRK2KITAURKAAURKB | |
| SCHEMBL12728156 | 0.78 | MTOR (1.00) | MTOR | |
| SCHEMBL12773481 | 0.75 | MTOR (0.68) | MTORALOX5APFEN1 | |
| SCHEMBL722106 | 0.74 | MTOR (0.47) | MTORLRRK2KITAURKAAURKB | |
| SCHEMBL7877513 | 0.73 | GABRP (0.51) | MTORMAP4K4 | |
| SCHEMBL12773470 | 0.73 | MTOR (0.67) | MTORMAP4K4GCK | |
| SCHEMBL12773423 | 0.73 | MTOR (0.71) | MTOR | |
| SCHEMBL14844630 | 0.72 | MTOR (0.49) | MTORLRRK2AURKAAURKBINCENP | |
| SCHEMBL22736088 | 0.72 | AURKA (0.52) | MTORLRRK2AURKAAURKBINCENP | |
| SCHEMBL30522547 | 0.71 | MTOR (0.52) | MTORGRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110098275-A1 | 5-ALKYNYL-PYRIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-04-28 | — | — | US | disclosed |
| WO-2010122069-A1 | 5-ALKYNYL-PYRIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098275-A1 | 5-ALKYNYL-PYRIDINES | MKI67, KIT, CCNA1 | MTOR 1220/4885LRRK2 1078/4885KIT 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.