Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 19/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 18/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL556638 | 0.94 | REN (0.82) | RENKCNH2CYP3A4SCN9A | |
| SCHEMBL557413 | 0.84 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL10202769 | 0.82 | REN (0.83) | RENKCNH2CYP3A4SCN9A | |
| SCHEMBL7872858 | 0.81 | REN (0.91) | RENKCNH2CYP3A4 | |
| SCHEMBL556663 | 0.79 | KCNH2 (0.60) | RENKCNH2CYP3A4SCN9A | |
| SCHEMBL10202561 | 0.78 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL10202823 | 0.77 | REN (0.81) | RENKCNH2CYP3A4 | |
| SCHEMBL10202564 | 0.77 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL10202814 | 0.77 | REN (0.82) | RENKCNH2CYP3A4 | |
| SCHEMBL556664 | 0.76 | KCNH2 (0.56) | RENKCNH2CYP3A4SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |