Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 4/20 | 0.47 |
| ▸ | GRM5 | P41594 | 2/20 | 0.47 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.47 |
| ▸ | SLC6A12 | P48065 | 4/20 | 0.38 |
| ▸ | SLC6A11 | P48066 | 4/20 | 0.38 |
| ▸ | SLC6A13 | Q9NSD5 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.31 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | GRM8 | O00222 | 1/20 | 0.31 |
| ▸ | GRM6 | O15303 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9875452 | 0.75 | GRM2 (0.43) | GRM2GRM5GRM1SLC6A12SLC6A11 | |
| SCHEMBL3926736 | 0.74 | GRM2 (0.42) | GRM2GRM5GRM1SLC6A12SLC6A11 | |
| SCHEMBL11612533 | 0.72 | GRM2 (0.37) | GRM2GRM5GRM1HSD11B1CYP1A2 | |
| SCHEMBL339517 | 0.72 | SLC6A12 (0.46) | GRM2GRM5GRM1SLC6A12SLC6A11 | |
| SCHEMBL4452499 | 0.72 | SLC6A12 (0.46) | GRM2GRM5GRM1SLC6A12SLC6A11 | |
| SCHEMBL1029829 | 0.72 | SLC6A12 (0.46) | GRM2GRM5GRM1SLC6A12SLC6A11 | |
| SCHEMBL24904452 | 0.70 | — | — | |
| SCHEMBL19982481 | 0.67 | GRM2 (0.39) | GRM2GRM5GRM1SLC6A12SLC6A11 | |
| SCHEMBL144394 | 0.65 | — | — | |
| SCHEMBL16535275 | 0.65 | GRM2 (1.00) | GRM2GRM5GRM1GRM3GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133481-A1 | QUINOLINE AND QUINOXALINE COMPOUNDS AS PDGF-R AND/OR LCK TYROSINE KINASE INHIBITORS | Aventis Pharmaceuticals Products Inc. (US) | 2001-09-19 | — | — | EP | disclosed |
| WO-2000031049-A1 | QUINOLINE AND QUINOXALINE COMPOUNDS AS PDGF-R AND/OR LCK TYROSINE KINASE INHIBITORS | AVENTIS PHARMACEUTICALS PRODUCTS INC. (US) | 2000-06-02 | — | — | WO | disclosed |