Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28786616 | 0.86 | POLB (0.36) | POLBTSHRNPSR1MEN1KMT2A | |
| SCHEMBL2656076 | 0.83 | ALDH1A1 (0.41) | POLBTSHRNPSR1MEN1KMT2A | |
| SCHEMBL2657588 | 0.82 | GSK3B (0.42) | POLBTSHRMEN1KMT2ANR1I2 | |
| SCHEMBL2669831 | 0.77 | KDM4E (0.31) | POLBMEN1KMT2AKDM4E | |
| SCHEMBL5363394 | 0.75 | TSHR (0.52) | POLBTSHRNPSR1MEN1KMT2A | |
| SCHEMBL2656358 | 0.75 | SMN1; SMN2 (0.42) | POLBTSHRTP53KDM4E | |
| SCHEMBL6829825 | 0.73 | TDP1 (0.49) | POLBTSHRNPSR1MEN1KMT2A | |
| SCHEMBL1107375 | 0.72 | KDM4E (0.38) | POLBTSHRNPSR1MEN1KMT2A | |
| SCHEMBL1107411 | 0.71 | SMN1; SMN2 (0.43) | POLBTSHRTDP1TP53CA1 | |
| SCHEMBL18486629 | 0.70 | MEN1 (0.61) | POLBTSHRNPSR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310093-B1 | ADMINISTERING, IN AMOUNT EFFECTIVE TO REDUCE DAMAGE TO NEURONAL CELLS, COMPOUND WHICH SELECTIVELY INHIBITS EXTRACELLULAR GLUTAMINASE RELATIVE TO GLUTAMINASE PRESENT IN INTACT CELLS AND IS IMPERMEABLE TO INTACT CELL MEMBRANES | ELAN PHARMACEUTICALS, INC. | 2001-10-30 | — | — | US | disclosed |
| WO-1999009825-A1 | METHOD OF PREVENTING NEURONAL DEATH | ELAN PHARMACEUTICALS, INC. (US) | 1999-03-04 | — | — | WO | disclosed |