Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7872820 | 0.93 | HDAC1 (0.48) | HDAC1HDAC6FLT4KDRHPGD | |
| SCHEMBL21317389 | 0.81 | CDK1 (0.50) | HDAC1HDAC6HPGDCCNB2CDK1 | |
| SCHEMBL9230643 | 0.81 | HDAC6 (0.58) | HDAC1HDAC6FLT4KDRNSD3 | |
| SCHEMBL7867774 | 0.80 | HSP90AA1 (0.39) | HDAC1FLT4KDRHDAC2KMT2A | |
| SCHEMBL7878997 | 0.77 | DOT1L (0.35) | HDAC1HDAC6FLT4KDRHPGD | |
| SCHEMBL14175360 | 0.77 | CDK1 (0.48) | PDE4DTDP1EGFRCCNB2CDK1 | |
| SCHEMBL14175378 | 0.77 | CCNB2 (0.46) | HDAC1HDAC6HPGDEGFRCCNB2 | |
| SCHEMBL7166671 | 0.77 | NSD3 (0.43) | HDAC1HDAC6HPGDPDE4APDE4B | |
| SCHEMBL8150599 | 0.77 | HDAC1 (0.35) | HDAC1HDAC6FLT4KDRHPGD | |
| SCHEMBL9583386 | 0.75 | CDK1 (0.44) | HDAC1HDAC6KMT2ACCNB2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316595-B1 | PNA synthesis using a base-labile amino protecting group | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-11-13 | — | — | US | disclosed |
| US-6121418-A | PNA synthesis using a base-labile amino protecting group | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-09-19 | — | — | US | disclosed |