Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 1/20 | 1.00 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.57 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.57 |
| ▸ | DPP4 | P27487 | 2/20 | 0.53 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.53 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.50 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | TGM2 | P21980 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7382206 | 0.99 | ANPEP (0.98) | ANPEPDPP8DPP7DPP4DPP9 | |
| SCHEMBL7873431 | 0.87 | ANPEP (0.77) | ANPEPDPP8DPP7HTT | |
| SCHEMBL31060496 | 0.85 | ANPEP (0.73) | ANPEPDPP8DPP7DPP4DPP9 | |
| SCHEMBL7321298 | 0.83 | ANPEP (0.71) | ANPEPDPP8DPP7DPP4DPP9 | |
| SCHEMBL17646248 | 0.83 | ANPEP (0.71) | ANPEPDPP8DPP7DPP4DPP9 | |
| SCHEMBL19680371 | 0.83 | ANPEP (0.71) | ANPEPDPP8DPP7DPP4DPP9 | |
| SCHEMBL7382201 | 0.83 | ANPEP (0.71) | ANPEPDPP8DPP7DPP4DPP9 | |
| Hydrochloric Acid SCHEMBL28344217 | 0.82 | ANPEP (0.70) | ANPEPDPP8DPP7DPP4DPP9 | |
| Hydrochloric Acid SCHEMBL17646311 | 0.82 | ANPEP (0.70) | ANPEPDPP8DPP7DPP4DPP9 | |
| SCHEMBL7318869 | 0.81 | ANPEP (0.68) | ANPEPDPP8DPP7DPP4DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |