Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.31 |
| ▸ | SETD2 | Q9BYW2 | 1/20 | 0.31 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7880788 | 0.90 | AR (0.35) | MTNR1AMTNR1BHRH4FLT3IDO1 | |
| SCHEMBL7881317 | 0.88 | AR (0.35) | MTNR1AMTNR1BHRH4FLT3IDO1 | |
| SCHEMBL7873285 | 0.88 | MAPT (0.39) | MTNR1AMTNR1BHRH4FLT3IDO1 | |
| SCHEMBL7880167 | 0.84 | MTNR1A (0.33) | MTNR1AMTNR1BHRH4FLT3IDO1 | |
| SCHEMBL7873970 | 0.84 | KDM4E (0.30) | — | |
| SCHEMBL7881991 | 0.83 | MTNR1A (0.35) | MTNR1AMTNR1BHRH4FLT3IDO1 | |
| SCHEMBL7873969 | 0.83 | CARM1 (0.38) | MTNR1AMTNR1BHRH4FLT3IDO1 | |
| SCHEMBL7873249 | 0.82 | — | — | |
| SCHEMBL7882052 | 0.82 | PLAU (0.38) | MTNR1AMTNR1BHRH4FLT3IDO1 | |
| SCHEMBL7878084 | 0.81 | BRD4 (0.39) | MTNR1AMTNR1BHRH4FLT3NSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248772-B1 | HYPOTENSIVE AGENTS; ANTIARRHYTHMIA AGENTS; ANTIDIABETIC AGENTS; ANTIPROLIFERATIVE AGENTS | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2001-06-19 | — | — | US | disclosed |
| US-6169107-B1 | USEFUL FOR THE TREATMENT AND PREVENTION OF DISEASES CAUSED BY INCREASED SODIUM/PROTON (NA.SUP.+ /H.SUP.+) EXCHANGER ACTIVITY, FOR EXAMPLE, HYPERTENSION, ARRHYTHMIA, ANGINA PECTORIS, CARDIAC HYPERTROPHY, DIABETES MELLITUS | SUMITOMO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-0708091-A2 | Indoloylguanidine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-04-24 | — | — | EP | disclosed |