Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | KMO | O15229 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7671999 | 0.86 | TSHR (0.55) | TSHRLMNACHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL27924572 | 0.83 | TSHR (0.52) | TSHRLMNACHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL3879951 | 0.83 | TSHR (0.52) | TSHRLMNACHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL20299326 | 0.83 | TSHR (0.52) | TSHRLMNACHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL15994783 | 0.81 | F2 (0.53) | TSHRLMNACHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL4998342 | 0.81 | LMNA (0.54) | TSHRLMNACHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL11298055 | 0.81 | MAPT (0.52) | TSHRLMNACHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL27771387 | 0.81 | LMNA (0.54) | TSHRLMNACHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL27771390 | 0.81 | TSHR (0.48) | TSHRLMNACHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL11248630 | 0.80 | NPY5R (0.50) | TSHRLMNACHRNB2CHRNA4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1067928-A4 | METHODS FOR INHIBITING MRP1 | LILLY CO ELI (US) | 2001-11-14 | — | — | EP | disclosed |
| EP-1067928-A1 | METHODS FOR INHIBITING MRP1 | ELI LILLY AND COMPANY (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999051228-A1 | METHODS FOR INHIBITING MRP1 | ELI LILLY AND COMPANY (US) | 1999-10-14 | — | — | WO | disclosed |