SCHEMBL7874137

SCHEMBL7874137

O=C1Nc2ccccc2C1=Cc1ccc2ccccc2n1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 1/20 0.59
TLK2 Q86UE8 2/20 0.53
FLT3 P36888 4/20 0.52
PDGFRB P09619 3/20 0.52
CSF1R P07333 2/20 0.52
EGFR P00533 1/20 0.52
KIT P10721 1/20 0.52
PIM1 P11309 1/20 0.51
MAPT P10636 2/20 0.50
CDK5 Q00535 2/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
KDR P35968 2/20 0.50
RET P07949 2/20 0.50
PTK2B Q14289 1/20 0.50
CDK5R1 Q15078 1/20 0.50
SYK P43405 1/20 0.50
ATM Q13315 1/20 0.50
MEN1 O00255 1/20 0.50
LMNA P02545 1/20 0.50
KMT2A Q03164 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8291555 1.00 GSK3B (0.59) GSK3BTLK2FLT3PDGFRBCSF1R
SCHEMBL13080586 0.84 FLT3 (0.56) FLT3PDGFRBCSF1REGFRKIT
SCHEMBL13080589 0.84 LRRK2 (0.61) PDGFRBRETRPS6KA3LRRK2
SCHEMBL7138968 0.84 MAPT (0.49) GSK3BTLK2FLT3PDGFRBCSF1R
SCHEMBL1388519 0.84 RET (0.54) GSK3BTLK2FLT3PDGFRBCSF1R
SCHEMBL1388393 0.84 PDPK1 (0.54) GSK3BFLT3PDGFRBCSF1REGFR
SCHEMBL31237606 0.83 GSK3B (0.72) GSK3BTLK2FLT3PDGFRBCSF1R
SCHEMBL1388800 0.81 TLK2 (0.57) TLK2PDGFRBCSF1REGFRKIT
SCHEMBL9045746 0.81 EGFR (0.54) GSK3BTLK2FLT3PDGFRBCSF1R
SCHEMBL13080905 0.81 GSK3B (0.67) GSK3BPDGFRBMAPTSMN1; SMN2RET

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0684820-B1 BIOLOGICALLY ACTIVE 3-SUBSTITUTED OXINDOLE DERIVATIVES USEFUL AS ANTI-ANGIOGENIC AGENTS PHARMACIA & UPJOHN SPA (IT) 2001-08-16 EP claimed
EP-0662473-B1 2-Oxindole derivatives as tyrosine kinase inhibitors PHARMACIA & UPJOHN SPA (IT) 1999-09-01 EP claimed
US-5905149-A CHEMICAL CONDENSATION OF ALDEHYDE WITH INDOLONE COMPOUND PHARMACIA & UPJOHN S.P.A (IT) 1999-05-18 US claimed
EP-0876365-A1 SUBSTITUTED QUINOLYLMETHYLEN-OXINDOLE ANALOGUES AS TYROSINE KINASE INHIBITORS PHARMACIA & UPJOHN S.p.A. (IT) 1998-11-11 EP claimed
WO-1997046551-A1 SUBSTITUTED QUINOLYLMETHYLEN-OXINDOLE ANALOGUES AS TYROSINE KINASE INHIBITORS PHARMACIA & UPJOHN S.P.A. (IT) 1997-12-11 WO claimed
US-5488057-A ENZYME INHIBITORS AND ANTICARCINOGENIC AGENTS FARMITALIA CARLO ERBA S.R.L. (IT) 1996-01-30 US claimed
EP-0662473-A1 2-Oxindole derivatives as tyrosine kinase inhibitors PHARMACIA S.p.A. (IT) 1995-07-12 EP claimed
EP-1918277-B1 Azulene compounds IND TECH RES INST (TW) 2015-06-10 EP disclosed
EP-0684820-B1 BIOLOGICALLY ACTIVE 3-SUBSTITUTED OXINDOLE DERIVATIVES USEFUL AS ANTI-ANGIOGENIC AGENTS PHARMACIA & UPJOHN SPA (IT) 2001-08-16 EP disclosed
EP-0662473-B1 2-Oxindole derivatives as tyrosine kinase inhibitors PHARMACIA & UPJOHN SPA (IT) 1999-09-01 EP disclosed
US-5905149-A CHEMICAL CONDENSATION OF ALDEHYDE WITH INDOLONE COMPOUND PHARMACIA & UPJOHN S.P.A (IT) 1999-05-18 US disclosed
US-5905149-A CHEMICAL CONDENSATION OF ALDEHYDE WITH INDOLONE COMPOUND PHARMACIA & UPJOHN S.P.A (IT) 1999-05-18 US disclosed
EP-0876365-A1 SUBSTITUTED QUINOLYLMETHYLEN-OXINDOLE ANALOGUES AS TYROSINE KINASE INHIBITORS PHARMACIA & UPJOHN S.p.A. (IT) 1998-11-11 EP disclosed
US-5627207-A CANCER FARMITALIA CARLO ERBA S R L (IT) 1997-05-06 US disclosed
US-5488057-A ENZYME INHIBITORS AND ANTICARCINOGENIC AGENTS FARMITALIA CARLO ERBA S.R.L. (IT) 1996-01-30 US disclosed
EP-0684820-A1 BIOLOGICALLY ACTIVE 3-SUBSTITUTED OXINDOLE DERIVATIVES USEFUL AS ANTI-ANGIOGENIC AGENTS PHARMACIA & UPJOHN S.p.A. (IT) 1995-12-06 EP disclosed
EP-0662473-A1 2-Oxindole derivatives as tyrosine kinase inhibitors PHARMACIA S.p.A. (IT) 1995-07-12 EP disclosed
WO-1995017181-A1 BIOLOGICALLY ACTIVE 3-SUBSTITUTED OXINDOLE DERIVATIVES USEFUL AS ANTI-ANGIOGENIC AGENTS PHARMACIA S.P.A. (IT) 1995-06-29 WO disclosed
US-5374652-A Substituted naphthylmethylene- or tetrahydronaphthylmethylene-derivatives of 2-oxoindole FARMITALIA CARLO ERBA S R L (IT) 1994-12-20 US disclosed
WO-1991013055-A2 NEW ARYL- AND HETEROARYLETHENYLENE DERIVATIVES AND PROCESS FOR THEIR PREPARATION FARMITALIA CARLO ERBA S.R.L. (IT) 1991-09-05 WO disclosed