Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLK2 | Q86UE8 | 8/20 | 0.57 |
| ▸ | JAK3 | P52333 | 2/20 | 0.57 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.57 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 4/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.47 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1388393 | 0.85 | PDPK1 (0.54) | PDPK1PIM1MEN1KMT2AKDR | |
| SCHEMBL13080586 | 0.82 | FLT3 (0.56) | PIM1MEN1KMT2AKDRPDGFRB | |
| SCHEMBL7138968 | 0.82 | MAPT (0.49) | TLK2PIM1MEN1KMT2AKDR | |
| SCHEMBL13080589 | 0.82 | LRRK2 (0.61) | PDGFRB | |
| SCHEMBL1388519 | 0.82 | RET (0.54) | TLK2PDPK1PIM1MEN1KMT2A | |
| SCHEMBL8291555 | 0.81 | GSK3B (0.59) | TLK2JAK3PIM1MEN1KMT2A | |
| SCHEMBL7874137 | 0.81 | GSK3B (0.59) | TLK2JAK3PIM1MEN1KMT2A | |
| SCHEMBL13080905 | 0.79 | GSK3B (0.67) | JAK3MEN1KMT2APDGFRBCDK2 | |
| SCHEMBL7132958 | 0.78 | PDGFRB (0.43) | TLK2PDPK1PIM1MEN1KMT2A | |
| SCHEMBL7138017 | 0.76 | SRC (0.52) | PDPK1KDRPDGFRBFGFR1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656654-A | TYROSINE KINASE INHIBITORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1997-08-12 | — | — | US | claimed |
| JP-H08500847-A | — | — | 1996-01-30 | — | — | JP | claimed |
| EP-0658159-A1 | ARYLIDENE AND HETEROARYLIDENE OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-06-21 | — | — | EP | claimed |
| WO-1995001349-A1 | ARYLIDENE AND HETEROARYLIDENE OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1995-01-12 | — | — | WO | claimed |
| EP-0987263-B1 | Arylidene and heteroarylidene oxindole derivatives as tyrosine kinase inhibitors | PFIZER ITALIA SRL (IT) | 2007-04-18 | — | — | EP | disclosed |
| EP-0987263-A2 | Arylidene and heteroarylidene oxindole derivatives as tyrosine kinase inhibitors | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-03-22 | — | — | EP | disclosed |
| US-5656654-A | TYROSINE KINASE INHIBITORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1997-08-12 | — | — | US | disclosed |
| EP-0658159-A1 | ARYLIDENE AND HETEROARYLIDENE OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-06-21 | — | — | EP | disclosed |
| WO-1995001349-A1 | ARYLIDENE AND HETEROARYLIDENE OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1995-01-12 | — | — | WO | disclosed |