Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 19/20 | 0.56 |
| ▸ | RXRB | P28702 | 10/20 | 0.51 |
| ▸ | RXRG | P48443 | 10/20 | 0.51 |
| ▸ | RARB | P10826 | 6/20 | 0.51 |
| ▸ | RARG | P13631 | 6/20 | 0.51 |
| ▸ | RARA | P10276 | 5/20 | 0.51 |
| ▸ | PPARG | P37231 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.44 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6902498 | 0.87 | RXRA (0.60) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL7870773 | 0.87 | RXRA (0.61) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL8330713 | 0.85 | RXRA (0.49) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL1072538 | 0.85 | RXRA (0.67) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL6890738 | 0.83 | RXRA (0.78) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL12426169 | 0.83 | RXRA (0.60) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL5537864 | 0.81 | RXRA (0.59) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL14212722 | 0.80 | RXRA (0.52) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL6890125 | 0.80 | RXRA (0.72) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL8330521 | 0.78 | RXRA (0.51) | RXRARXRBRXRGRARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6320074-B1 | IN VIVO MODULATION OF LIPID METABOLISM, SKIN-RELATED PROCESSES, AUTOIMMUNE DISEASES, FATTY ACID METABOLISM, MALIGNANT CELL DEVELOPMENT, PREMALIGNANT LESIONS, OR PROGRAMMED CELL DEATH | LIGAND PHARMACEUTICALS INCORPORATED | 2001-11-20 | — | — | US | claimed |
| EP-0678086-B1 | COMPOUNDS HAVING SELECTIVITY FOR RETINOID X RECEPTORS | LIGAND PHARM INC (US) | 1999-12-08 | — | — | EP | claimed |
| EP-0678086-A1 | COMPOUNDS HAVING SELECTIVITY FOR RETINOID X RECEPTORS | LIGAND PHARMACEUTICALS, INC. (US) | 1995-10-25 | — | — | EP | claimed |
| WO-1994015902-A1 | COMPOUNDS HAVING SELECTIVITY FOR RETINOID X RECEPTORS | LIGAND PHARMACEUTICALS INC. (US) | 1994-07-21 | — | — | WO | claimed |