Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.73 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.69 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.61 |
| ▸ | PTGES | O14684 | 1/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.61 |
| ▸ | CA12 | O43570 | 1/20 | 0.61 |
| ▸ | PDE5A | O76074 | 1/20 | 0.61 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.61 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.61 |
| ▸ | CA1 | P00915 | 1/20 | 0.61 |
| ▸ | CA2 | P00918 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | CA3 | P07451 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7876235 | 0.91 | PTGS2 (0.73) | PTGS2CYP2C9PTGS1PDPK1PTGES | |
| SCHEMBL7876663 | 0.87 | PTGS2 (0.74) | PTGS2CYP2C9PTGS1PDPK1PTGES | |
| SCHEMBL7876231 | 0.86 | PTGS2 (0.73) | PTGS2CYP2C9PTGS1PDPK1PTGES | |
| SCHEMBL6725486 | 0.86 | PTGS2 (0.56) | PTGS2CYP2C9PTGS1PDPK1PTGES | |
| SCHEMBL8953883 | 0.86 | PTGS2 (0.80) | PTGS2CYP2C9PTGS1PDPK1PTGES | |
| SCHEMBL6516184 | 0.86 | PTGS2 (0.80) | PTGS2CYP2C9PTGS1PDPK1PTGES | |
| SCHEMBL7874455 | 0.86 | PTGS2 (0.67) | PTGS2CYP2C9PTGS1 | |
| SCHEMBL6730050 | 0.86 | PTGS2 (0.54) | PTGS2CYP2C9PTGS1PDPK1PTGES | |
| SCHEMBL7876247 | 0.85 | PTGS2 (0.74) | PTGS2CYP2C9PTGS1PDPK1PTGES | |
| SCHEMBL27552855 | 0.85 | PTGS2 (0.64) | PTGS2CYP2C9PTGS1PDPK1PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316485-B1 | INHIBITS ACTIVITY OF CYCLOOXYGENASE-2; FOR THERAPY AND PROPHYLAXIS OF INFLAMMATION, THROMBOSIS, RHEUMATOID ARTHRITIS, ALZHEIMER'S DISEASE; AS ANALGESIC | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| EP-1017678-A1 | 1,5-DIPHENYLPYRAZOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-07-12 | — | — | EP | disclosed |
| WO-1999015505-A1 | 1,5-DIPHENYLPYRAZOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-04-01 | — | — | WO | disclosed |