Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 4/20 | 0.63 |
| ▸ | CA9 | Q16790 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.50 |
| ▸ | RPA1 | P27694 | 1/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7867789 | 0.93 | CHRNA7 (0.63) | CHRNA7CA9SMN1; SMN2PTGS2RPA1 | |
| SCHEMBL7874469 | 0.89 | CHRNA7 (0.66) | CHRNA7CA9SMN1; SMN2PTGS2RPA1 | |
| SCHEMBL7876435 | 0.89 | CHRNA7 (0.63) | CHRNA7CA9SMN1; SMN2PTGS2MAPK9 | |
| SCHEMBL7872741 | 0.87 | CHRNA7 (0.66) | CHRNA7CA9SMN1; SMN2PTGS2RPA1 | |
| SCHEMBL7878961 | 0.87 | CA9 (0.62) | CHRNA7CA9SMN1; SMN2PTGS2MAPK9 | |
| SCHEMBL7876676 | 0.87 | CHRNA7 (0.63) | CHRNA7CA9SMN1; SMN2PTGS2MAPK9 | |
| SCHEMBL9199925 | 0.85 | CA9 (0.68) | CHRNA7CA9PTGS2RPA1PTGS1 | |
| SCHEMBL9204895 | 0.84 | CA9 (0.82) | CHRNA7CA9SMN1; SMN2PTGS2PTGS1 | |
| SCHEMBL6511261 | 0.82 | CA9 (0.69) | CHRNA7CA9SMN1; SMN2PTGS2 | |
| SCHEMBL7627415 | 0.82 | CHRNA7 (0.83) | CHRNA7CA9PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316485-B1 | INHIBITS ACTIVITY OF CYCLOOXYGENASE-2; FOR THERAPY AND PROPHYLAXIS OF INFLAMMATION, THROMBOSIS, RHEUMATOID ARTHRITIS, ALZHEIMER'S DISEASE; AS ANALGESIC | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |