Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 3/20 | 0.82 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.69 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9199282 | 0.91 | CA9 (0.72) | CA9CHRNA7PTGS2HDAC3HDAC1 | |
| SCHEMBL6511261 | 0.91 | CA9 (0.69) | CA9CHRNA7PTGS2HDAC3HDAC1 | |
| SCHEMBL7627415 | 0.91 | CHRNA7 (0.83) | CA9CHRNA7PTGS2PTGS1 | |
| SCHEMBL9210036 | 0.91 | CA9 (0.75) | CA9CHRNA7PTGS2ALOX5NR1H2 | |
| SCHEMBL9941326 | 0.91 | CA9 (0.82) | CA9CHRNA7PTGS2ALOX5PTGS1 | |
| SCHEMBL8922996 | 0.90 | CA9 (0.68) | CA9CHRNA7PTGS2ALOX5SMN1; SMN2 | |
| SCHEMBL8925232 | 0.90 | CA9 (0.68) | CA9CHRNA7PTGS2HDAC3HDAC1 | |
| SCHEMBL9199925 | 0.90 | CA9 (0.68) | CA9CHRNA7PTGS2PTGS1 | |
| SCHEMBL9202722 | 0.90 | CA9 (0.67) | CA9CHRNA7PTGS2HDAC3HDAC1 | |
| SCHEMBL6343758 | 0.90 | CA9 (1.00) | CA9CHRNA7PTGS2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5134142-A | PYRAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |