Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7867703 | 0.96 | EGFR (0.45) | EGFRP4HTMCA2EGLN1KMT2A | |
| SCHEMBL7870463 | 0.95 | KMT2A (0.46) | EGFRP4HTMEGLN1KMT2AL3MBTL1 | |
| SCHEMBL9574842 | 0.94 | EGFR (0.43) | EGFRP4HTMCA2KMT2AL3MBTL1 | |
| SCHEMBL7869460 | 0.94 | EGFR (0.43) | EGFRP4HTMCA2KMT2AL3MBTL1 | |
| SCHEMBL7874619 | 0.93 | HPGD (0.47) | EGFRP4HTMEGLN1KMT2AL3MBTL1 | |
| SCHEMBL7862692 | 0.93 | EGFR (0.43) | EGFRP4HTMCA2CA12CA9 | |
| SCHEMBL7867827 | 0.92 | KMT2A (0.42) | EGFRP4HTMCA2KMT2AL3MBTL1 | |
| SCHEMBL7870447 | 0.90 | HSD17B10 (0.41) | P4HTMEGLN1KMT2AGABRA5RAB9A | |
| SCHEMBL7871556 | 0.90 | CA2 (0.47) | EGFRCA2KMT2AL3MBTL1HPGD | |
| SCHEMBL7871681 | 0.89 | EGFR (0.46) | EGFRP4HTMCA2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |