Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL788348 | 0.90 | KDR (0.63) | KDRMAPTTP53MEN1KMT2A | |
| SCHEMBL787470 | 0.83 | KDR (0.52) | KDRCSNK2A1MAPTCSNK2A2CSNK2B | |
| SCHEMBL788156 | 0.83 | KDR (0.67) | KDRMAPTTP53MEN1KMT2A | |
| SCHEMBL787835 | 0.83 | KDR (0.53) | KDRCSNK2A1MAPTCSNK2A2CSNK2B | |
| SCHEMBL787760 | 0.77 | MAPK1 (0.43) | KDRMAPTTP53KDM4E | |
| SCHEMBL806102 | 0.76 | KDR (0.68) | KDRMAPTTP53MEN1KMT2A | |
| SCHEMBL806103 | 0.74 | KDR (0.78) | KDRMAPTTP53MEN1KMT2A | |
| SCHEMBL806125 | 0.74 | KDR (0.72) | KDRMAPTMEN1KMT2A | |
| SCHEMBL788175 | 0.74 | KDR (0.78) | KDRMAPTMEN1KMT2AKDM4E | |
| SCHEMBL788057 | 0.74 | KDR (0.77) | KDRMAPTTP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616443-A1 | PHTALAZINE DERIVATIVES AS JAK1 INHIBITORS | Exelixis, Inc. (US) | 2013-07-24 | — | — | EP | claimed |
| WO-2012037132-A1 | PHTALAZINE DERIVATIVES AS JAK1 INHIBITORS | EXELIXIS, INC. (US) | 2012-03-22 | — | — | WO | claimed |