Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.75 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | ESR1 | P03372 | 2/20 | 0.55 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL6633071 | 0.97 | CYP3A4 (0.80) | CYP3A4TDP1ALDH1A1ESR1ESR2 | |
| Biphenyl SCHEMBL4383765 | 0.94 | CYP3A4 (0.75) | CYP3A4TDP1ALDH1A1ESR1ESR2 | |
| Biphenyl SCHEMBL4381705 | 0.94 | CYP3A4 (0.75) | CYP3A4TDP1ALDH1A1ESR1ESR2 | |
| Biphenyl SCHEMBL27510461 | 0.94 | CYP3A4 (0.75) | CYP3A4TDP1ALDH1A1ESR1ESR2 | |
| SCHEMBL19262009 | 0.91 | CYP3A4 (0.71) | CYP3A4TDP1ALDH1A1ESR1ESR2 | |
| SCHEMBL30388209 | 0.91 | CYP3A4 (0.71) | CYP3A4TDP1ALDH1A1ESR1ESR2 | |
| SCHEMBL2018959 | 0.91 | CYP3A4 (0.71) | CYP3A4TDP1ALDH1A1ESR1ESR2 | |
| Bromide SCHEMBL1409552 | 0.90 | TDP1 (0.92) | CYP3A4TDP1ALDH1A1ESR1ESR2 | |
| Bromide SCHEMBL1409549 | 0.90 | TDP1 (0.92) | CYP3A4TDP1ALDH1A1ESR1ESR2 | |
| Bromide SCHEMBL3314443 | 0.90 | TDP1 (0.92) | CYP3A4TDP1ALDH1A1ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316575-B1 | MELT TRANSESTERIFICATION OF DIOL COMPOUND AND CARBOANTE COMPOUND USING CATALYST COMPRISING A PHOSPHORUS-CONTAINING BASIC COMPOUND QUATERNARY PHOSPHONIUM SALT TO FORM POLYCARBONATE | IDEMITSU KOSAN CO., LTD. (JP) | 2001-11-13 | — | — | US | claimed |