Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 7/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.35 |
| ▸ | MTOR | P42345 | 3/20 | 0.34 |
| ▸ | AKT1 | P31749 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | STAT1 | P42224 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL584589 | 0.92 | DGAT1 (0.38) | DGAT1PIK3CAMTORAKT1KDM4E | |
| SCHEMBL595034 | 0.86 | DGAT1 (0.41) | DGAT1PIK3CAMTORAKT1KDM4E | |
| SCHEMBL7881024 | 0.85 | PIK3CA (0.33) | DGAT1PIK3CAMTORAKT1KDM4E | |
| SCHEMBL2680181 | 0.84 | DGAT1 (0.36) | DGAT1PIK3CAMTORAKT1AVPR1B | |
| SCHEMBL10239396 | 0.83 | PIK3CA (0.34) | DGAT1PIK3CAMTORAKT1KDM4E | |
| SCHEMBL584172 | 0.81 | DGAT1 (0.51) | DGAT1MTORKDM4EL3MBTL1JAK2 | |
| SCHEMBL2679762 | 0.80 | DGAT1 (0.35) | DGAT1PIK3CAMTORAKT1KDM4E | |
| SCHEMBL7874285 | 0.80 | CHEK1 (0.34) | PIK3CAMTORAKT1 | |
| SCHEMBL1074879 | 0.80 | DGAT1 (0.49) | DGAT1MTORKDM4EL3MBTL1JAK2 | |
| SCHEMBL2680019 | 0.79 | CHEK1 (0.31) | MTORJAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |