Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 11/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.39 |
| ▸ | AKT1 | P31749 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 3/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2680297 | 0.90 | CHEK1 (0.44) | DGAT1PIK3CAAKT1MTOREGFR | |
| SCHEMBL583494 | 0.90 | CHEK1 (0.44) | DGAT1PIK3CAAKT1MTOREGFR | |
| SCHEMBL10237251 | 0.90 | CHEK1 (0.44) | DGAT1PIK3CAAKT1MTOREGFR | |
| SCHEMBL7882445 | 0.90 | CHEK1 (0.45) | DGAT1PIK3CAAKT1MTOREGFR | |
| SCHEMBL2679709 | 0.90 | CHEK1 (0.44) | DGAT1PIK3CAAKT1MTOREGFR | |
| SCHEMBL2679919 | 0.88 | CHEK1 (0.42) | DGAT1PIK3CAAKT1MTOREGFR | |
| SCHEMBL10237291 | 0.88 | DGAT1 (0.39) | DGAT1PIK3CAAKT1MTOREGFR | |
| SCHEMBL7882121 | 0.87 | CHEK1 (0.44) | DGAT1PIK3CAAKT1MTOREGFR | |
| SCHEMBL7878568 | 0.86 | MEN1 (0.44) | DGAT1PIK3CAAKT1MTORKCNH2 | |
| SCHEMBL10237285 | 0.86 | CHEK1 (0.45) | DGAT1PIK3CAAKT1MTORCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |