Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 7/20 | 0.37 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.36 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.36 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | PIR | O00625 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.36 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | STK16 | O75716 | 1/20 | 0.36 |
| ▸ | OXSR1 | O95747 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | FES | P07332 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | YES1 | P07947 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7876631 | 0.96 | BRAF (0.38) | BRAFPAK1MAP2K4BMPR1BPLK4 | |
| SCHEMBL298370 | 0.84 | CYP2C19 (0.49) | BRAFPAK1MAP2K4BMPR1BPLK4 | |
| SCHEMBL7876453 | 0.84 | BTK (0.42) | PAK1MAP2K4STK16NEK2TNIK | |
| SCHEMBL298856 | 0.83 | CYP2C19 (0.49) | BRAFPAK1MAP2K4BMPR1BPLK4 | |
| SCHEMBL7872497 | 0.83 | BRAF (0.56) | BRAFPAK1MAP2K4BMPR1BPLK4 | |
| SCHEMBL7869096 | 0.82 | CYP3A4 (0.45) | BRAFPAK1MAP2K4BMPR1BPLK4 | |
| SCHEMBL7878749 | 0.82 | BRAF (0.50) | BRAFPAK1MAP2K4BMPR1BPLK4 | |
| SCHEMBL7880231 | 0.81 | CYP3A4 (0.53) | BRAFKITCYP2C19CYP2C9CYP3A4 | |
| SCHEMBL298381 | 0.79 | BRAF (0.44) | BRAFMAP2K4NEK2MAP2K1CYP2C9 | |
| SCHEMBL7869062 | 0.79 | CYP3A4 (0.44) | BRAFKITRIPK1CYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129570-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | PLEXXIKON, INC. (US) | 2010-11-11 | — | — | WO | disclosed |