Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.61 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | DRD5 | P21918 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | G6PD | P11413 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7874803 | 1.00 | DRD2 (0.61) | DRD2HSD11B1ADRA2AADRA2BADRA2C | |
| SCHEMBL7886601 | 1.00 | DRD2 (0.61) | DRD2HSD11B1ADRA2AADRA2BADRA2C | |
| SCHEMBL7880605 | 1.00 | DRD2 (0.61) | DRD2HSD11B1ADRA2AADRA2BADRA2C | |
| Bromide SCHEMBL243103 | 0.98 | DRD2 (0.60) | DRD2HSD11B1ADRA2AADRA2BADRA2C | |
| Bromide SCHEMBL240587 | 0.98 | DRD2 (0.60) | DRD2HSD11B1ADRA2AADRA2BADRA2C | |
| Bromide SCHEMBL240352 | 0.98 | DRD2 (0.60) | DRD2HSD11B1ADRA2AADRA2BADRA2C | |
| Bromide SCHEMBL239049 | 0.98 | DRD2 (0.60) | DRD2HSD11B1ADRA2AADRA2BADRA2C | |
| SCHEMBL244216 | 0.90 | DRD2 (0.76) | DRD2HSD11B1ADRA2AADRA2BADRA2C | |
| SCHEMBL241076 | 0.90 | DRD2 (0.76) | DRD2HSD11B1ADRA2AADRA2BADRA2C | |
| SCHEMBL7885978 | 0.90 | DRD2 (0.76) | DRD2HSD11B1ADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010097087-A1 | CATECHOLAMINE DERIVATIVES AND PRODRUGS THEREOF | H. LUNDBECK A/S (DK) | 2010-09-02 | — | — | WO | disclosed |