Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | AHR | P35869 | 4/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.50 |
| ▸ | F7 | P08709 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | F3 | P13726 | 1/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.46 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20968236 | 0.72 | AHR (0.43) | USP2GAAALOX15RAD51NPSR1 | |
| SCHEMBL14436669 | 0.71 | CYP1A2 (0.32) | CYP2A6CYP1A2 | |
| SCHEMBL50566 | 0.71 | USP2 (1.00) | USP2GAAALOX15RAD51NPSR1 | |
| SCHEMBL9095490 | 0.71 | AHR (0.56) | USP2GAAALOX15RAD51NPSR1 | |
| SCHEMBL29440252 | 0.71 | USP2 (1.00) | USP2GAAALOX15RAD51NPSR1 | |
| SCHEMBL10204893 | 0.71 | USP2 (0.50) | USP2GAAALOX15RAD51NPSR1 | |
| SCHEMBL5850255 | 0.70 | NPC1 (0.79) | USP2GAAALOX15RAD51NPSR1 | |
| SCHEMBL16760922 | 0.70 | AHR (0.41) | USP2GAAALOX15RAD51NPSR1 | |
| Bromide SCHEMBL6029763 | 0.70 | USP2 (0.95) | USP2GAAALOX15RAD51NPSR1 | |
| Water SCHEMBL28220544 | 0.70 | USP2 (0.95) | USP2GAAALOX15RAD51NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2722329-A1 | Indol-amide compounds as beta-amyloid inhbitors | F. Hoffmann-La Roche AG (CH) | 2014-04-23 | — | — | EP | disclosed |
| WO-2010129467-A1 | COMPOUNDS AND METHODS FOR INHIBITION OF RENIN, AND INDICATIONS THEREFOR | PLEXXIKON, INC. (US) | 2010-11-11 | — | — | WO | disclosed |