Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 19/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 14/20 | 0.44 |
| ▸ | PLAT | P00750 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4186541 | 0.86 | PTGS2 (0.59) | PTGS2PTGS1PLAT | |
| SCHEMBL4180069 | 0.86 | PTGS2 (0.59) | PTGS2PTGS1PLAT | |
| SCHEMBL4192320 | 0.86 | PTGS2 (0.53) | PTGS2PTGS1 | |
| SCHEMBL4186485 | 0.85 | PTGS2 (0.58) | PTGS2PTGS1 | |
| SCHEMBL4189637 | 0.80 | PTGS2 (0.59) | PTGS2PTGS1 | |
| SCHEMBL4187833 | 0.80 | PTGS2 (0.64) | PTGS2PTGS1 | |
| SCHEMBL4177757 | 0.78 | PTGS2 (0.57) | PTGS2PTGS1PLAT | |
| SCHEMBL4192319 | 0.78 | PTGS2 (0.54) | PTGS2PTGS1 | |
| SCHEMBL4187837 | 0.77 | PTGS2 (0.62) | PTGS2PTGS1 | |
| SCHEMBL4192816 | 0.76 | PTGS2 (0.70) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6307047-B1 | PYRIDAZINONE COMPOUNDS; INHIBITORS OF CYCLOOXYGENASE-2 (COX-2); SELECTIVITY OF THESE COMPOUNDS FOR COX-2 MINIMIZES THE UNWANTED GI AND RENAL SIDE-EFFECTS SEEN WITH CURRENTLY MARKETED NON-STEROIDAL ANTI-INFLAMMATORY DRUGS | ABBOTT LABORATORIES | 2001-10-23 | — | — | US | disclosed |